Pde3a MGI Mouse Gene Detail - MGI:1860764 - phosphodiesterase 3A, cGMP inhibited

Symbol

Pde3a
Name

phosphodiesterase 3A, cGMP inhibited
Synonyms

A930022O17Rik

Feature Type

protein coding gene
IDs

MGI:1860764
NCBI Gene: 54611
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:141194995-141452588 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 71.87 cM, cytoband G1
Mapping Data

3 experiments

SNPs within 2kb

8310 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860764	protein coding gene	Chr6:141194995-141453174 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031451	protein coding gene	Chr6:145994661-146264224 (+)
A/J	MGP_AJ_G0031426	protein coding gene	Chr6:140220225-140478538 (+)
AKR/J	MGP_AKRJ_G0031354	protein coding gene	Chr6:144420635-144689682 (+)
BALB/cJ	MGP_BALBcJ_G0031433	protein coding gene	Chr6:140050970-140312826 (+)
C3H/HeJ	MGP_C3HHeJ_G0031155	protein coding gene	Chr6:144489763-144752497 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031895	protein coding gene	Chr6:149988371-150261532 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029025	protein coding gene	Chr6:139070234-139317928 (+)
CAST/EiJ	MGP_CASTEiJ_G0030523	protein coding gene	Chr6:144037778-144307615 (+)
CBA/J	MGP_CBAJ_G0031115	protein coding gene	Chr6:155718995-155997296 (+)
DBA/2J	MGP_DBA2J_G0031272	protein coding gene	Chr6:139061658-139318776 (+)
FVB/NJ	MGP_FVBNJ_G0031223	protein coding gene	Chr6:137851559-138110002 (+)
LP/J	MGP_LPJ_G0031356	protein coding gene	Chr6:146141832-146405919 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031263	protein coding gene	Chr6:159559672-159861292 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031927	protein coding gene	Chr6:144255127-144521181 (+)
PWK/PhJ	MGP_PWKPhJ_G0030250	protein coding gene	Chr6:137564352-137844479 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030074	protein coding gene	Chr6:142473344-142746465 (+)
WSB/EiJ	MGP_WSBEiJ_G0030616	protein coding gene	Chr6:144901433-145163972 (+)

Human Ortholog

PDE3A, phosphodiesterase 3A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE3A, phosphodiesterase 3A
Synonyms

CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB
Links

HGNC:8778

NCBI Gene ID: 5139

neXtProt AC: NX_Q14432

UniProt: Q14432
Chr Location

12p12.2; chr12:20368537-20688583 (+) GRCh38

MGI Vertebrate Homology

Pde3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE3A
Gene Tree

Pde3a

Diseases

1 with human PDE3A associations

				Human Disease	Mouse Models
				hypertension and brachydactyly syndrome IDs hypertension and brachydactyly syndrome DOID:0111247 MESH:C537095 OMIM:112410 ORDO:1276 UMLS_CUI:C1862170

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display female infertility with oocyte arrest.

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All GO Annotations

46
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1108
Tissues

126
cDNA Data

19
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde3a

ZFIN pde3a

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All Sequences

50
RefSeq

6
UniProt

3
CCDS

CCDS20676.1

Ensembl

ENSMUSG00000041741 (Evidence)
NCBI Gene

54611

			Length	Strain/Species	Flank
genomic	54611	NCBI Gene Model \| MGI Sequence Detail	257594	C57BL/6J	± kb
transcript	NM_018779	RefSeq \| MGI Sequence Detail	10794	C57BL/6
polypeptide	Q9Z0X4	UniProt \| EBI \| MGI Sequence Detail	1141	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012470 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

(term hierarchy)
EC

3.1.4.-, 3.1.4.17
InterPro Domains

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR003607 HD/PDEase domain

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All nucleic 24

cDNA 20

Primer pair 4

Microarray probesets 4

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MGI:2141790, MGI:2442709

Summaries

All 62

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 16
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:354224 Van Wauwe J, et al., PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates. Life Sci Alliance. 2024 Dec;7(12)

TSS for Pde3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59446	Chr6:141194887-141194901 (+)	-101 bp
Tssr59447	Chr6:141195710-141195724 (+)	722 bp
Tssr59448	Chr6:141220680-141220698 (+)	25,694 bp
Tssr59449	Chr6:141220701-141220717 (+)	25,714 bp
Tssr59450	Chr6:141220735-141220751 (+)	25,748 bp
Tssr59451	Chr6:141220809-141220843 (+)	25,831 bp
Tssr59452	Chr6:141221053-141221066 (+)	26,065 bp
Tssr59453	Chr6:141242702-141242707 (+)	47,710 bp
Tssr59454	Chr6:141352505-141352516 (+)	157,516 bp
Tssr59455	Chr6:141400467-141400471 (+)	205,474 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24