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Creb3l1 Gene Detail
Summary
  • Symbol
    Creb3l1
  • Name
    cAMP responsive element binding protein 3-like 1
  • Synonyms
    BBF-2 (drosophila) homolog, MGC:25246, Oasis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347062
    NCBI Gene: 26427
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91812673-91854515 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.63 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1090 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347062
 protein coding gene Chr2:91812673-91854847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026162
 protein coding gene Chr2:93374692-93420593 (-)
A/J MGP_AJ_G0026123
 protein coding gene Chr2:89607968-89650166 (-)
AKR/J MGP_AKRJ_G0026104
 protein coding gene Chr2:92085014-92127114 (-)
BALB/cJ MGP_BALBcJ_G0026132
 protein coding gene Chr2:89794242-89837927 (-)
C3H/HeJ MGP_C3HHeJ_G0025883
 protein coding gene Chr2:92388049-92430199 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026583
 protein coding gene Chr2:96597705-96644519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023974
 protein coding gene Chr2:86101169-86143950 (-)
CAST/EiJ MGP_CASTEiJ_G0025348
 protein coding gene Chr2:92923522-92971879 (-)
CBA/J MGP_CBAJ_G0025861
 protein coding gene Chr2:99943124-99992641 (-)
DBA/2J MGP_DBA2J_G0025997
 protein coding gene Chr2:89204281-89248462 (-)
FVB/NJ MGP_FVBNJ_G0025960
 protein coding gene Chr2:88312889-88355784 (-)
LP/J MGP_LPJ_G0026101
 protein coding gene Chr2:93570317-93618652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025986
 protein coding gene Chr2:102937151-102982732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026637
 protein coding gene Chr2:92168562-92212142 (-)
PWK/PhJ MGP_PWKPhJ_G0025083
 protein coding gene Chr2:88942745-88986042 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024884
 protein coding gene Chr2:91731324-91778592 (-)
WSB/EiJ MGP_WSBEiJ_G0025415
 protein coding gene Chr2:92777039-92823946 (-)



Homology
more
  • Human Ortholog
    CREB3L1, cAMP responsive element binding protein 3 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3L1, cAMP responsive element binding protein 3 like 1
  • Synonyms
    C16DELp11.2, DEL16p11.2, OASIS, OI16
  • Links
    NCBI Gene ID: 90993
    neXtProt AC: NX_Q96BA8
    UniProt: Q96BA8

  • Chr Location
    11p11.2; chr11:46277662-46321409 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CREB3L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal growth retardation, fragile skeleton, and decreased bone density, cortical and trabecular thickness, and osteoblast maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    128
  • cDNA Data
    59
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26427 NCBI Gene Model | MGI Sequence Detail 41843 C57BL/6J ±  kb
    transcript NM_011957 RefSeq | MGI Sequence Detail 2284 FVB/N  
    polypeptide Q9Z125 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005856 cyclic AMP-responsive element-binding protein 3-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
    • GlyGen
      Q9Z125 4 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 60
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory