Cog1 MGI Mouse Gene Detail - MGI:1333873 - component of oligomeric golgi complex 1

Symbol

Cog1
Name

component of oligomeric golgi complex 1

Feature Type

protein coding gene
IDs

MGI:1333873
NCBI Gene: 16834
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:113539995-113557880 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 79.10 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

650 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333873	protein coding gene	Chr11:113539995-113560157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019351	protein coding gene	Chr11:117478033-117497485 (+)
A/J	MGP_AJ_G0019319	protein coding gene	Chr11:112416506-112434724 (+)
AKR/J	MGP_AKRJ_G0019288	protein coding gene	Chr11:115723121-115743344 (+)
BALB/cJ	MGP_BALBcJ_G0019293	protein coding gene	Chr11:112823428-112843745 (+)
C3H/HeJ	MGP_C3HHeJ_G0019102	protein coding gene	Chr11:116072322-116095034 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019743	protein coding gene	Chr11:121001161-121022136 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017366	protein coding gene	Chr11:109492326-109510900 (+)
CAST/EiJ	MGP_CASTEiJ_G0018655	protein coding gene	Chr11:117347212-117364642 (+)
CBA/J	MGP_CBAJ_G0019071	protein coding gene	Chr11:125933271-125953980 (+)
DBA/2J	MGP_DBA2J_G0019183	protein coding gene	Chr11:111853148-111867235 (+)
FVB/NJ	MGP_FVBNJ_G0019174	protein coding gene	Chr11:111327578-111349057 (+)
LP/J	MGP_LPJ_G0019253	protein coding gene	Chr11:117909395-117933751 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019205	protein coding gene	Chr11:125083309-125104114 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019780	protein coding gene	Chr11:116374150-116396477 (+)
PWK/PhJ	MGP_PWKPhJ_G0018420	protein coding gene	Chr11:113061832-113081824 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018212	protein coding gene	Chr11:116188764-116207175 (+)
WSB/EiJ	MGP_WSBEiJ_G0018707	protein coding gene	Chr11:116336436-116356770 (+)

Human Ortholog

COG1, component of oligomeric golgi complex 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COG1, component of oligomeric golgi complex 1
Synonyms

CDG2G, LDLB
Links

HGNC:6545

NCBI Gene ID: 9382

neXtProt AC: NX_Q8WTW3

UniProt: Q8WTW3
Chr Location

17q25.1; chr17:73193055-73208507 (+) GRCh38

MGI Vertebrate Homology

Cog1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COG1
Gene Tree

Cog1

Diseases

1 with human COG1 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type IIg IDs congenital disorder of glycosylation type IIg DOID:0070259 MESH:C535756 OMIM:611209 ORDO:263508 UMLS_CUI:C2931011

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
1 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture.

less

All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

3
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cog1

less

All Sequences

96
RefSeq

12
UniProt

12
CCDS

CCDS25599.1

Ensembl

ENSMUSG00000018661 (Evidence)
NCBI Gene

16834

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018661	Ensembl Gene Model \| MGI Sequence Detail	17886	C57BL/6J	± kb
transcript	ENSMUST00000018805	Ensembl \| MGI Sequence Detail	3935	Not Applicable
polypeptide	ENSMUSP00000018805	Ensembl \| MGI Sequence Detail	980	Not Applicable

less

UniProt

12 Sequences
Protein Ontology

PR:000005684 conserved oligomeric Golgi complex subunit 1

(term hierarchy)
InterPro Domains

IPR033370 Conserved oligomeric Golgi complex subunit 1
GlyGen

Q9Z160 1 site, 1 O-linked glycan (1 site)

less

All nucleic 11

cDNA 11

Microarray probesets 5

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:52531 Chatterton JE, et al., Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):915-20
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cog1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105753	Chr11:113540345-113540386 (+)	371 bp
Tssr105754	Chr11:113540403-113540410 (+)	412 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24