Dedd MGI Mouse Gene Detail - MGI:1333874 - death effector domain-containing

Symbol

Dedd
Name

death effector domain-containing
Synonyms

CASP8IP1, Dedpro1, DEFT, FLDED1, KE05

Feature Type

protein coding gene
IDs

MGI:1333874
NCBI Gene: 21945
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:171156713-171169899 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.34 cM, cytoband H2
Mapping Data

3 experiments

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333874	protein coding gene	Chr1:171152229-171170843 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016755	protein coding gene	Chr1:177119656-177136531 (+)
A/J	MGP_AJ_G0016735	protein coding gene	Chr1:169904951-169918071 (+)
AKR/J	MGP_AKRJ_G0016701	protein coding gene	Chr1:175000467-175013682 (+)
BALB/cJ	MGP_BALBcJ_G0016696	protein coding gene	Chr1:170396994-170410835 (+)
C3H/HeJ	MGP_C3HHeJ_G0016519	protein coding gene	Chr1:175242162-175255940 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017157	protein coding gene	Chr1:183011932-183027968 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014865	protein coding gene	Chr1:161590987-161605443 (+)
CAST/EiJ	MGP_CASTEiJ_G0016100	protein coding gene	Chr1:174875044-174888055 (+)
CBA/J	MGP_CBAJ_G0016494	protein coding gene	Chr1:189517375-189535608 (+)
DBA/2J	MGP_DBA2J_G0016601	protein coding gene	Chr1:168747284-168760638 (+)
FVB/NJ	MGP_FVBNJ_G0016597	protein coding gene	Chr1:167096054-167109227 (+)
LP/J	MGP_LPJ_G0016672	protein coding gene	Chr1:178236777-178250326 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016624	protein coding gene	Chr1:196801004-196814951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017194	protein coding gene	Chr1:174866670-174879755 (+)
PWK/PhJ	MGP_PWKPhJ_G0015886	protein coding gene	Chr1:167969634-167982935 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015670	protein coding gene	Chr1:173651791-173666608 (+)
WSB/EiJ	MGP_WSBEiJ_G0016162	protein coding gene	Chr1:174984860-174998978 (+)

Human Ortholog

DEDD, death effector domain containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEDD, death effector domain containing
Synonyms

CASP8IP1, DEDD1, DEDPro1, DEFT, FLDED-1, FLDED1, KE05
Links

HGNC:2755

NCBI Gene ID: 9191

neXtProt AC: NX_O75618

UniProt: O75618
Chr Location

1q23.3; chr1:161120974-161132688 (-) GRCh38

MGI Vertebrate Homology

Dedd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DEDD
Gene Tree

Dedd

less

Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

29
Targeted

1
Transgenic

1
Genomic Mutations

2 involving Dedd
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display reduced body size, organ size and organ weight without reductions in cell numbers.

less

All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

29
cDNA Data

25
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DEDD

Xenbase dedd

less

All Sequences

108
RefSeq

36
UniProt

8
CCDS

CCDS15490.1

Ensembl

ENSMUSG00000013973 (Evidence)
NCBI Gene

21945

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013973	Ensembl Gene Model \| MGI Sequence Detail	13187	C57BL/6J	± kb
transcript	ENSMUST00000097467	Ensembl \| MGI Sequence Detail	1606	Not Applicable
polypeptide	ENSMUSP00000095075	Ensembl \| MGI Sequence Detail	318	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000006375 death effector domain-containing protein

(term hierarchy)
InterPro Domains

IPR001875 Death effector domain

IPR038856 Death effector domain-containing protein

IPR011029 Death-like domain superfamily

IPR049341 TRADD-like N-terminal domain

less

All nucleic 25

cDNA 25

Microarray probesets 5

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:50530 Stegh AH, et al., DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86
Latest

J:171849 Mori M, et al., Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011 Jan 4;121(1):318-27

TSS for Dedd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10011	Chr1:171156583-171156595 (+)	-124 bp
Tssr10012	Chr1:171156944-171156972 (+)	245 bp
Tssr10013	Chr1:171157016-171157069 (+)	330 bp
Tssr10014	Chr1:171157191-171157221 (+)	493 bp
Tssr10015	Chr1:171158690-171158697 (+)	1,981 bp
Tssr10016	Chr1:171158908-171158926 (+)	2,204 bp
Tssr10017	Chr1:171158930-171158942 (+)	2,223 bp
Tssr10018	Chr1:171158982-171158986 (+)	2,271 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24