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Gab2 Gene Detail
Summary
  • Symbol
    Gab2
  • Name
    growth factor receptor bound protein 2-associated protein 2
  • Synonyms
    D130058I17Rik, p97
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333854
    NCBI Gene: 14389
  • Alliance
    gene page
  • Transcription Start Sites
    40 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:96730958-96958158 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.39 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333854
 protein coding gene Chr7:96730793-96958158 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032519
 protein coding gene Chr7:99773833-99988836 (+)
A/J MGP_AJ_G0032493
 protein coding gene Chr7:97302732-97511026 (+)
AKR/J MGP_AKRJ_G0032429
 protein coding gene Chr7:99605220-99824484 (+)
BALB/cJ MGP_BALBcJ_G0032504
 protein coding gene Chr7:96992465-97204924 (+)
C3H/HeJ MGP_C3HHeJ_G0032219
 protein coding gene Chr7:99978000-100192656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033002
 protein coding gene Chr7:103646856-103884762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029997
 protein coding gene Chr7:99778939-99974528 (+)
CAST/EiJ MGP_CASTEiJ_G0031546
 protein coding gene Chr7:91494554-91701943 (+)
CBA/J MGP_CBAJ_G0032186
 protein coding gene Chr7:107162926-107395446 (+)
DBA/2J MGP_DBA2J_G0032338
 protein coding gene Chr7:95685045-95879888 (+)
FVB/NJ MGP_FVBNJ_G0032294
 protein coding gene Chr7:95451541-95657692 (+)
LP/J MGP_LPJ_G0032427
 protein coding gene Chr7:101094764-101315026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032327
 protein coding gene Chr7:108707037-108939897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033024
 protein coding gene Chr7:98925763-99127393 (+)
PWK/PhJ MGP_PWKPhJ_G0031264
 protein coding gene Chr7:88730120-88933554 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031107
 protein coding gene Chr7:86161650-86362397 (+)
WSB/EiJ MGP_WSBEiJ_G0031663
 protein coding gene Chr7:99554233-99764190 (+)



Homology
more
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
  • Links
    NCBI Gene ID: 9846
    neXtProt AC: NX_Q9UQC2
    UniProt: Q9UQC2

  • Chr Location
    11q14.1; chr11:78215293-78418348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 6 alleles in 6 genetic backgrounds
    15 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in passive cutaneous and systemic anaphylaxis, Fc gamma receptor-mediated phagocytosis, and mast cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    41
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14389 NCBI Gene Model | MGI Sequence Detail 227201 C57BL/6J ±  kb
    transcript NM_010248 RefSeq | MGI Sequence Detail 6008 C57BL/6  
    polypeptide Q9Z1S8 UniProt | EBI | MGI Sequence Detail 665 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007754 GRB2-associated-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR046355 GRB2-associated-binding protein 1-4-like
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
    • GlyGen
      Q9Z1S8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141977, MGI:2441947
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 68
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory