Homer1 MGI Mouse Gene Detail - MGI:1347345 - homer scaffolding protein 1

Symbol

Homer1
Name

homer scaffolding protein 1
Synonyms

PSD-Zip45, Ves-1

Feature Type

protein coding gene
IDs

MGI:1347345
NCBI Gene: 26556
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:93436143-93541637 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 47.83 cM
Mapping Data

2 experiments

SNPs within 2kb

2245 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347345	protein coding gene	Chr13:93436143-93549471 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020824	protein coding gene	Chr13:94634931-94738411 (+)
A/J	MGP_AJ_G0020778	protein coding gene	Chr13:91124135-91224036 (+)
AKR/J	MGP_AKRJ_G0020751	protein coding gene	Chr13:93905870-94007267 (+)
BALB/cJ	MGP_BALBcJ_G0020774	protein coding gene	Chr13:91772033-91872829 (+)
C3H/HeJ	MGP_C3HHeJ_G0020568	protein coding gene	Chr13:93583150-93689310 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021211	protein coding gene	Chr13:97526680-97630163 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018778	protein coding gene	Chr13:87018717-87116756 (+)
CAST/EiJ	MGP_CASTEiJ_G0020087	protein coding gene	Chr13:92841480-92952952 (+)
CBA/J	MGP_CBAJ_G0020527	protein coding gene	Chr13:101377128-101493272 (+)
DBA/2J	MGP_DBA2J_G0020652	protein coding gene	Chr13:90905078-91006402 (+)
FVB/NJ	MGP_FVBNJ_G0020632	protein coding gene	Chr13:89702946-89803652 (+)
LP/J	MGP_LPJ_G0020725	protein coding gene	Chr13:94753507-94859421 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020661	protein coding gene	Chr13:101884612-102018016 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021251	protein coding gene	Chr13:93281294-93381554 (+)
PWK/PhJ	MGP_PWKPhJ_G0019839	protein coding gene	Chr13:89610072-89711762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019663	protein coding gene	Chr13:89557371-89669645 (+)
WSB/EiJ	MGP_WSBEiJ_G0020144	protein coding gene	Chr13:93776355-93880662 (+)

Human Ortholog

HOMER1, homer scaffold protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOMER1, homer scaffold protein 1
Synonyms

HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Links

HGNC:17512

NCBI Gene ID: 9456

neXtProt AC: NX_Q86YM7

UniProt: Q86YM7
Chr Location

5q14.1; chr5:79372636-79514134 (-) GRCh38

MGI Vertebrate Homology

Homer1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOMER1
Gene Tree

Homer1

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Targeted

3
Genomic Mutations

1 involving Homer1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit an increase in spontaneous calcium influx in pancreatic acinar cells. Mice homozygous for a knock-out allele exhibit decreased response to formalin-induced pain.

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All GO Annotations

82
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

976
Tissues

195
cDNA Data

36
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOMER1

Xenbase homer1

ZFIN homer1b

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All Sequences

82
RefSeq

14
UniProt

9
CCDS

CCDS26687.1, CCDS36745.1, CCDS36746.1, CCDS70484.1, CCDS84048.1

Ensembl

ENSMUSG00000007617 (Evidence)
NCBI Gene

26556

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007617	Ensembl Gene Model \| MGI Sequence Detail	105495	C57BL/6J	± kb
transcript	ENSMUST00000079086	Ensembl \| MGI Sequence Detail	4287	Not Applicable
polypeptide	ENSMUSP00000078093	Ensembl \| MGI Sequence Detail	370	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008678 homer protein homolog 1

(term hierarchy)
InterPro Domains

IPR044100 Homer, EVH1 domain

IPR045027 Homer family

IPR011993 PH-like domain superfamily

IPR000697 WH1/EVH1 domain
GlyGen

Q9Z2Y3 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 38

cDNA 36

Primer pair 1

Other 1

Microarray probesets 6

Summaries

All 119

Developmental Gene Expression 16

Gene Ontology 27

Phenotypes 36
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:342051 Koutsioumpa C, et al., Skin-type-dependent development of murine mechanosensory neurons. Dev Cell. 2023 Oct 23;58(20):2032-2047.e6

TSS for Homer1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120647	Chr13:93436137-93436154 (+)	3 bp
Tssr120648	Chr13:93437725-93437756 (+)	1,598 bp
Tssr120649	Chr13:93440282-93440296 (+)	4,146 bp
Tssr120650	Chr13:93440574-93440646 (+)	4,467 bp
Tssr120651	Chr13:93441430-93441443 (+)	5,294 bp
Tssr120652	Chr13:93441448-93441463 (+)	5,313 bp
Tssr120653	Chr13:93444514-93444537 (+)	8,383 bp
Tssr120654	Chr13:93476749-93476758 (+)	40,611 bp
Tssr120655	Chr13:93476790-93476801 (+)	40,653 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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