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Cib2 Gene Detail
Summary
  • Symbol
    Cib2
  • Name
    calcium and integrin binding family member 2
  • Synonyms
    2810434I23Rik, calcium binding protein Kip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929293
    NCBI Gene: 56506
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54452078-54467502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929293
protein coding gene Chr9:54452074-54467512 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034825
protein coding gene Chr9:53586116-53601439 (-)
A/J MGP_AJ_G0034806
protein coding gene Chr9:51882113-51897497 (-)
AKR/J MGP_AKRJ_G0034734
protein coding gene Chr9:53059654-53074962 (-)
BALB/cJ MGP_BALBcJ_G0034798
protein coding gene Chr9:51656215-51673309 (-)
C3H/HeJ MGP_C3HHeJ_G0034508
protein coding gene Chr9:53520018-53539270 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035317
protein coding gene Chr9:55090237-55110648 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032229
protein coding gene Chr9:51296658-51312026 (-)
CAST/EiJ MGP_CASTEiJ_G0033830
protein coding gene Chr9:53531871-53547138 (-)
CBA/J MGP_CBAJ_G0034479
protein coding gene Chr9:56983377-57003978 (-)
DBA/2J MGP_DBA2J_G0034638
protein coding gene Chr9:51771865-51787560 (-)
FVB/NJ MGP_FVBNJ_G0034580
protein coding gene Chr9:50975409-50990814 (-)
LP/J MGP_LPJ_G0034720
protein coding gene Chr9:53906052-53922694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034623
protein coding gene Chr9:58552718-58570809 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035339
protein coding gene Chr9:53056616-53071922 (-)
PWK/PhJ MGP_PWKPhJ_G0033534
protein coding gene Chr9:51747779-51763506 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033369
protein coding gene Chr9:53331547-53346752 (-)
WSB/EiJ MGP_WSBEiJ_G0033942
protein coding gene Chr9:53034141-53053733 (-)



Homology
more
  • Human Ortholog
    CIB2, calcium and integrin binding family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIB2, calcium and integrin binding family member 2
  • Synonyms
    DFNB48, KIP2, USH1J
  • Links
    NCBI Gene ID: 10518
    neXtProt AC: NX_O75838
    UniProt: O75838

  • Chr Location
    15q25.1; chr15:78104606-78131535 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Cib2 mouse models; 2 with human CIB2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal vestibular and retinal function but show an early onset profound deafness associated with abolished mechanoelectrical transduction currents and progressive postnatal degeneration of cochlear hair bundles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037493 Ensembl Gene Model | MGI Sequence Detail 15425 C57BL/6J ±  kb
    transcript ENSMUST00000041901 Ensembl | MGI Sequence Detail 1433 Not Applicable  
    polypeptide ENSMUSP00000038527 Ensembl | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915156, MGI:2143056
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349395 Lee JH, et al., The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat Commun. 2024 Jan 16;15(1):526

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory