Krt27 MGI Mouse Gene Detail - MGI:1339999

Symbol

Krt27
Name

keratin 27
Synonyms

Krt1-c29, mIRSa3.1, stpm

Feature Type

protein coding gene
IDs

MGI:1339999
NCBI Gene: 16675
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:99236391-99241930 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.92 cM
Mapping Data

5 experiments

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339999	protein coding gene	Chr11:99236391-99241944 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019089	protein coding gene	Chr11:102006078-102013131 (-)
A/J	MGP_AJ_G0019057	protein coding gene	Chr11:97712494-97718027 (-)
AKR/J	MGP_AKRJ_G0019027	protein coding gene	Chr11:100744684-100752633 (-)
BALB/cJ	MGP_BALBcJ_G0019031	protein coding gene	Chr11:98215641-98221189 (-)
C3H/HeJ	MGP_C3HHeJ_G0018844	protein coding gene	Chr11:100897078-100902604 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019482	protein coding gene	Chr11:105141168-105149080 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017114	protein coding gene	Chr11:95275216-95280792 (-)
CAST/EiJ	MGP_CASTEiJ_G0018399	protein coding gene	Chr11:101889095-101894645 (-)
CBA/J	MGP_CBAJ_G0018815	protein coding gene	Chr11:109526845-109532395 (-)
DBA/2J	MGP_DBA2J_G0018923	protein coding gene	Chr11:97274739-97280267 (-)
FVB/NJ	MGP_FVBNJ_G0018912	protein coding gene	Chr11:96790467-96795984 (-)
LP/J	MGP_LPJ_G0018993	protein coding gene	Chr11:102472821-102478345 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018939	protein coding gene	Chr11:109194461-109199997 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019522	protein coding gene	Chr11:101102594-101108145 (-)
PWK/PhJ	MGP_PWKPhJ_G0018170	protein coding gene	Chr11:98352012-98357550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017958	protein coding gene	Chr11:100860007-100865530 (-)
WSB/EiJ	MGP_WSBEiJ_G0018447	protein coding gene	Chr11:101076569-101083832 (-)

Human Ortholog

KRT27, keratin 27

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT27, keratin 27
Synonyms

K25IRS3, KRT25C
Links

HGNC:30841

NCBI Gene ID: 342574

neXtProt AC: NX_Q7Z3Y8

UniProt: Q7Z3Y8
Chr Location

17q21.2; chr17:40776808-40782550 (-) GRCh38

MGI Vertebrate Homology

Krt27 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT27
Gene Tree

Krt27

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
2 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Krt27
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Newborn heterozygotes show a slight bending of the whiskers. At ~P12, the coat develops a loose wave pattern. Whiskers of homozygotes are more curly and irregular while coat waviness occurs earlier and is more prominent. Adult coats are not waved but remains rough in texture.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

32
cDNA Data

60
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS25379.1

Ensembl

ENSMUSG00000017588 (Evidence)
NCBI Gene

16675

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017588	Ensembl Gene Model \| MGI Sequence Detail	5540	C57BL/6J	± kb
transcript	ENSMUST00000017732	Ensembl \| MGI Sequence Detail	1550	Not Applicable
polypeptide	ENSMUSP00000017732	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009466 keratin, type I cytoskeletal 27

(term hierarchy)
InterPro Domains

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I

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All nucleic 63

Genomic 1

cDNA 60

Primer pair 2

Microarray probesets 5

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MGI:3521999

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 20
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Krt27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110650	Chr11:99241912-99241939 (-)	4 bp
Tssr110649	Chr11:99240829-99240845 (-)	1,093 bp
Tssr110648	Chr11:99237361-99237365 (-)	4,567 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24