Slfn14 MGI Mouse Gene Detail - MGI:2684866

Symbol

Slfn14
Name

schlafen 14
Synonyms

LOC237890, Slfn14-ps

Feature Type

protein coding gene
IDs

MGI:2684866
NCBI Gene: 237890
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:83165936-83177552 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM
Mapping Data

2 experiments

SNPs within 2kb

167 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684866	protein coding gene	Chr11:83165936-83177552 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018843	protein coding gene	Chr11:84594058-84606106 (-)
A/J	MGP_AJ_G0018810	protein coding gene	Chr11:81382901-81394951 (-)
AKR/J	MGP_AKRJ_G0018780	protein coding gene	Chr11:83803781-83815755 (-)
BALB/cJ	MGP_BALBcJ_G0018783	protein coding gene	Chr11:81793639-81805660 (-)
C3H/HeJ	MGP_C3HHeJ_G0018597	protein coding gene	Chr11:83856737-83868726 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019235	protein coding gene	Chr11:87191845-87203882 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016869	protein coding gene	Chr11:78505056-78518311 (-)
CAST/EiJ	MGP_CASTEiJ_G0018152	protein coding gene	Chr11:84441823-84456023 (-)
CBA/J	MGP_CBAJ_G0018568	protein coding gene	Chr11:90968460-90980514 (-)
DBA/2J	MGP_DBA2J_G0018676	protein coding gene	Chr11:80979167-80992611 (-)
FVB/NJ	MGP_FVBNJ_G0018665	protein coding gene	Chr11:80461913-80474046 (-)
LP/J	MGP_LPJ_G0018746	protein coding gene	Chr11:85153061-85165091 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018692	protein coding gene	Chr11:91129713-91142813 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019275	protein coding gene	Chr11:84067653-84079654 (-)
PWK/PhJ	MGP_PWKPhJ_G0017921	protein coding gene	Chr11:81739299-81751612 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017713	protein coding gene	Chr11:83615894-83628063 (-)
WSB/EiJ	MGP_WSBEiJ_G0018203	protein coding gene	Chr11:83936021-83952985 (-)

Human Ortholog

SLFN14, schlafen family member 14

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLFN14, schlafen family member 14
Synonyms

BDPLT20
Links

HGNC:32689

NCBI Gene ID: 342618

neXtProt AC: NX_P0C7P3

UniProt: P0C7P3
Chr Location

17q12; chr17:35543985-35560819 (-) GRCh38

MGI Vertebrate Homology

Slfn14 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: SLFN14
Gene Tree

Slfn14

Diseases

1 with human SLFN14 associations

				Human Disease	Mouse Models
				platelet-type bleeding disorder 20 IDs platelet-type bleeding disorder 20 DOID:0111055 OMIM:616913 ORDO:466806

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Slfn14
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a K208N mutation do not survive to weaning. Heterozygotes show microcytic erythrocytosis, hemolytic anemia, splenomegaly and abnormal thrombus formation.

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All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

32
RefSeq

5
UniProt

1
CCDS

CCDS70269.1

Ensembl

ENSMUSG00000082101 (Evidence)
NCBI Gene

237890

			Length	Strain/Species	Flank
genomic	237890	NCBI Gene Model \| MGI Sequence Detail	11617	C57BL/6J	± kb
transcript	NM_001166028	RefSeq \| MGI Sequence Detail	3649	C57BL/6
polypeptide	V9GXG1	UniProt \| EBI \| MGI Sequence Detail	899	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032723 protein SLFN14

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain

IPR007421 Schlafen, AlbA_2 domain

IPR038461 Schlafen, AlbA_2 domain superfamily

IPR029684 Schlafen family

IPR048729 Schlafen, GTPase-like domain

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All nucleic 2

cDNA 2

Summaries

All 28

Gene Ontology 4

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slfn14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109652	Chr11:83177569-83177578 (-)	-22 bp
Tssr109651	Chr11:83177548-83177555 (-)	0 bp
Tssr109650	Chr11:83177506-83177525 (-)	36 bp
Tssr109649	Chr11:83177490-83177505 (-)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24