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B3gnt6 Gene Detail
Summary
  • Symbol
    B3gnt6
  • Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Synonyms
    Core-3, Core3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039603
    NCBI Gene: 272411
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97841622-97848682 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039603
 protein coding gene Chr7:97841622-97848688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032536
 protein coding gene Chr7:100920427-100927490 (-)
A/J MGP_AJ_G0032510
 protein coding gene Chr7:98429343-98436406 (-)
AKR/J MGP_AKRJ_G0032446
 protein coding gene Chr7:100767374-100774438 (-)
BALB/cJ MGP_BALBcJ_G0032521
 protein coding gene Chr7:98117413-98124476 (-)
C3H/HeJ MGP_C3HHeJ_G0032236
 protein coding gene Chr7:101123469-101130555 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033019
 protein coding gene Chr7:104833674-104840738 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030014
 protein coding gene Chr7:100879270-100886524 (-)
CAST/EiJ MGP_CASTEiJ_G0031563
 protein coding gene Chr7:92640290-92647357 (-)
CBA/J MGP_CBAJ_G0032203
 protein coding gene Chr7:108392300-108399386 (-)
DBA/2J MGP_DBA2J_G0032355
 protein coding gene Chr7:96762697-96769787 (-)
FVB/NJ MGP_FVBNJ_G0032311
 protein coding gene Chr7:96569005-96576068 (-)
LP/J MGP_LPJ_G0032444
 protein coding gene Chr7:102243569-102250636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032344
 protein coding gene Chr7:109926858-109933921 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033041
 protein coding gene Chr7:100042511-100049574 (-)
PWK/PhJ MGP_PWKPhJ_G0031281
 protein coding gene Chr7:89838032-89845113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031124
 protein coding gene Chr7:87307967-87315349 (-)
WSB/EiJ MGP_WSBEiJ_G0031680
 protein coding gene Chr7:100687454-100694528 (-)



Homology
more
  • Human Ortholog
    B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Synonyms
    B3Gn-T6, beta-1,3-Gn-T6, beta3Gn-T6, BGnT-6
  • Links
    NCBI Gene ID: 192134
    neXtProt AC: NX_Q6ZMB0
    UniProt: Q6ZMB0

  • Chr Location
    11q13.5; chr11:77034398-77041973 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozgous for a knock-out allele exhibit increased permeability of the intestinal barrier, increased susceptibility to DSS-induced colitis and accelerated colorectal tumorigenesis in mice treated with AOM and DSS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 272411 NCBI Gene Model | MGI Sequence Detail 7061 C57BL/6J ±  kb
    transcript NM_001081167 RefSeq | MGI Sequence Detail 2367 Not Specified  
    polypeptide Q3USF0 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:339673 Coletto E, et al., Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. Sci Rep. 2023 Aug 26;13(1):13982
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory