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Mapt Gene Detail
Summary
  • Symbol
    Mapt
  • Name
    microtubule-associated protein tau
  • Synonyms
    Mtapt, Tau
  • Feature Type
    protein coding gene
  • IDs
    MGI:97180
    NCBI Gene: 17762
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:104122216-104222916 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 67.79 cM, cytoband E1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97180
 protein coding gene Chr11:104120235-104222916 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019274
 protein coding gene Chr11:107376860-107479744 (+)
A/J MGP_AJ_G0019242
 protein coding gene Chr11:102807634-102905862 (+)
AKR/J MGP_AKRJ_G0019211
 protein coding gene Chr11:105949314-106051521 (+)
BALB/cJ MGP_BALBcJ_G0019216
 protein coding gene Chr11:103240093-103339811 (+)
C3H/HeJ MGP_C3HHeJ_G0019025
 protein coding gene Chr11:106185510-106289290 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019666
 protein coding gene Chr11:110695767-110800246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017291
 protein coding gene Chr11:100209588-100313372 (+)
CAST/EiJ MGP_CASTEiJ_G0018579
 protein coding gene Chr11:107232469-107342480 (+)
CBA/J MGP_CBAJ_G0018994
 protein coding gene Chr11:115285922-115401940 (+)
DBA/2J MGP_DBA2J_G0019106
 protein coding gene Chr11:102297742-102397739 (+)
FVB/NJ MGP_FVBNJ_G0019097
 protein coding gene Chr11:101830995-101936029 (+)
LP/J MGP_LPJ_G0019175
 protein coding gene Chr11:107844931-107951562 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019127
 protein coding gene Chr11:114606546-114706026 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019703
 protein coding gene Chr11:106348404-106447811 (+)
PWK/PhJ MGP_PWKPhJ_G0018343
 protein coding gene Chr11:103391842-103497595 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018134
 protein coding gene Chr11:106115662-106227459 (+)
WSB/EiJ MGP_WSBEiJ_G0018628
 protein coding gene Chr11:106351470-106460115 (+)



Homology
more
  • Human Ortholog
    MAPT, microtubule associated protein tau
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPT, microtubule associated protein tau
  • Synonyms
    DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, tau-40, Tau-PHF6
  • Links
    NCBI Gene ID: 4137
    neXtProt AC: NX_P10636
    UniProt: P10636

  • Chr Location
    17q21.31; chr17:45894527-46028334 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human MAPT associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 12 alleles in 11 genetic backgrounds
    100 phenotypes from multigenic genotypes
    1 images
    485 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1198
  • Tissues
    131
  • cDNA Data
    28
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018411 Ensembl Gene Model | MGI Sequence Detail 100701 C57BL/6J ±  kb
    transcript ENSMUST00000106989 Ensembl | MGI Sequence Detail 2250 Not Applicable  
    polypeptide ENSMUSP00000102602 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000010173 microtubule-associated protein tau
      (term hierarchy)
    • PDB
      6H0E, 8Q96
    • InterPro Domains
      IPR027324 Microtubule associated protein MAP2/MAP4/Tau
      IPR002955 Microtubule-associated protein Tau
      IPR001084 Microtubule associated protein, tubulin-binding repeat
    • GlyGen
      P10637 7 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 3
      cDNA 28
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478
    References
    more
    • Summaries
      All 821
      Developmental Gene Expression 83
      Diseases 5
      Gene Ontology 34
      Phenotypes 485
    • Earliest
      J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
    • Latest
      J:355385 Sala-Jarque J, et al., The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease. Sci Rep. 2024 Sep 16;14(1):21622
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory