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St3gal2 Gene Detail
Summary
  • Symbol
    St3gal2
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 2
  • Synonyms
    Siat5, ST3GalII
  • Feature Type
    protein coding gene
  • IDs
    MGI:99427
    NCBI Gene: 20444
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111646554-111699112 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99427
 protein coding gene Chr8:111646520-111699132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034131
 protein coding gene Chr8:113620819-113678501 (+)
A/J MGP_AJ_G0034110
 protein coding gene Chr8:109024222-109079606 (+)
AKR/J MGP_AKRJ_G0034037
 protein coding gene Chr8:112207747-112264200 (+)
BALB/cJ MGP_BALBcJ_G0034104
 protein coding gene Chr8:109203392-109257049 (+)
C3H/HeJ MGP_C3HHeJ_G0033815
 protein coding gene Chr8:112927610-112990667 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034624
 protein coding gene Chr8:117611085-117668833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031566
 protein coding gene Chr8:102010158-102066105 (+)
CAST/EiJ MGP_CASTEiJ_G0033142
 protein coding gene Chr8:112546484-112602219 (+)
CBA/J MGP_CBAJ_G0033789
 protein coding gene Chr8:121607225-121667633 (+)
DBA/2J MGP_DBA2J_G0033944
 protein coding gene Chr8:108317010-108370884 (+)
FVB/NJ MGP_FVBNJ_G0033888
 protein coding gene Chr8:107274060-107326728 (+)
LP/J MGP_LPJ_G0034034
 protein coding gene Chr8:113807868-113865062 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033934
 protein coding gene Chr8:124514984-124575126 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034643
 protein coding gene Chr8:112176466-112236467 (+)
PWK/PhJ MGP_PWKPhJ_G0032845
 protein coding gene Chr8:107895504-107950084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032684
 protein coding gene Chr8:110865660-110930156 (+)
WSB/EiJ MGP_WSBEiJ_G0033258
 protein coding gene Chr8:112866374-112924065 (+)



Homology
more
  • Human Ortholog
    ST3GAL2, ST3 beta-galactoside alpha-2,3-sialyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL2, ST3 beta-galactoside alpha-2,3-sialyltransferase 2
  • Synonyms
    Gal-NAc6S, SIAT4B, ST3GalA.2, ST3GALII
  • Links
    NCBI Gene ID: 6483
    neXtProt AC: NX_Q16842
    UniProt: Q16842

  • Chr Location
    16q22.1; chr16:70375977-70439237 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene apparently display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    118
  • cDNA Data
    68
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031749 Ensembl Gene Model | MGI Sequence Detail 52559 C57BL/6J ±  kb
    transcript ENSMUST00000034197 Ensembl | MGI Sequence Detail 4396 Not Applicable  
    polypeptide ENSMUSP00000034197 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16190, MGI:2142539, MGI:2142821
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:17521 Lee YC, et al., Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase. J Biol Chem. 1994 Apr 1;269(13):10028-33
    • Latest
      J:334166 Gonzalez-Gil A, et al., Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. J Biol Chem. 2022 Apr 20;298(6):101960
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory