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Mgat5b Gene Detail
Summary
  • Symbol
    Mgat5b
  • Name
    mannoside acetylglucosaminyltransferase 5, isoenzyme B
  • Synonyms
    GnT-IX
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606200
    NCBI Gene: 268510
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116809689-116877774 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606200
 protein coding gene Chr11:116809629-116877774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019444
 protein coding gene Chr11:121089957-121160395 (+)
A/J MGP_AJ_G0019412
 protein coding gene Chr11:115749385-115818240 (+)
AKR/J MGP_AKRJ_G0019382
 protein coding gene Chr11:119285963-119353990 (+)
BALB/cJ MGP_BALBcJ_G0019387
 protein coding gene Chr11:116137060-116205214 (+)
C3H/HeJ MGP_C3HHeJ_G0019193
 protein coding gene Chr11:119561211-119632242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019836
 protein coding gene Chr11:124814856-124889076 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017459
 protein coding gene Chr11:112755947-112846035 (+)
CAST/EiJ MGP_CASTEiJ_G0018747
 protein coding gene Chr11:120978289-121048567 (+)
CBA/J MGP_CBAJ_G0019164
 protein coding gene Chr11:129685637-129763356 (+)
DBA/2J MGP_DBA2J_G0019276
 protein coding gene Chr11:115167575-115236543 (+)
FVB/NJ MGP_FVBNJ_G0019268
 protein coding gene Chr11:114742440-114819861 (+)
LP/J MGP_LPJ_G0019346
 protein coding gene Chr11:121436411-121512279 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019301
 protein coding gene Chr11:128747962-128821627 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019875
 protein coding gene Chr11:119920931-119988927 (+)
PWK/PhJ MGP_PWKPhJ_G0018512
 protein coding gene Chr11:116505943-116575032 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018305
 protein coding gene Chr11:119650287-119722447 (+)
WSB/EiJ MGP_WSBEiJ_G0018799
 protein coding gene Chr11:119866390-119937886 (+)



Homology
more
  • Human Ortholog
    MGAT5B, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGAT5B, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  • Synonyms
    GnT-IX, GnT-VB
  • Links
    NCBI Gene ID: 146664
    neXtProt AC: NX_Q3V5L5
    UniProt: Q3V5L5

  • Chr Location
    17q25.2; chr17:76868404-76950393 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit low levels of O-man-linked beta1,6-branched glycans. Mice homozygous for a different knock-out allele exhibit decreased susceptibility to cuprizone induced injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    24
  • cDNA Data
    46
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043857 Ensembl Gene Model | MGI Sequence Detail 68086 C57BL/6J ±  kb
    transcript ENSMUST00000103027 Ensembl | MGI Sequence Detail 4258 Not Applicable  
    polypeptide ENSMUSP00000099316 Ensembl | MGI Sequence Detail 792 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010385 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
      (term hierarchy)
    • EC
      2.4.1.-, 2.4.1.155
    • InterPro Domains
      IPR052105 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
      IPR026116 Glycosyltransferase family 18
    • GlyGen
      Q765H6 4 sites, 4 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 46
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:248783 Xie WR, et al., An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 Sep 6;37(36):8583-8594
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory