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Fto Gene Detail
Summary
  • Symbol
    Fto
  • Name
    FTO alpha-ketoglutarate dependent dioxygenase
  • Synonyms
    mKIAA1752
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347093
    NCBI Gene: 26383
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:92040153-92395067 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9754 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347093
 protein coding gene Chr8:92039995-92395067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033932
 protein coding gene Chr8:92540390-92920957 (+)
A/J MGP_AJ_G0033915
 protein coding gene Chr8:88908058-89261747 (+)
AKR/J MGP_AKRJ_G0033841
 protein coding gene Chr8:91420658-91784720 (+)
BALB/cJ MGP_BALBcJ_G0033907
 protein coding gene Chr8:89072648-89433022 (+)
C3H/HeJ MGP_C3HHeJ_G0033617
 protein coding gene Chr8:92117323-92476856 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034428
 protein coding gene Chr8:95977604-96348589 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031369
 protein coding gene Chr8:82860125-83210132 (+)
CAST/EiJ MGP_CASTEiJ_G0032949
 protein coding gene Chr8:91614508-91999753 (+)
CBA/J MGP_CBAJ_G0033593
 protein coding gene Chr8:99199995-99572241 (+)
DBA/2J MGP_DBA2J_G0033747
 protein coding gene Chr8:88475519-88820102 (+)
FVB/NJ MGP_FVBNJ_G0033694
 protein coding gene Chr8:87408297-87751103 (+)
LP/J MGP_LPJ_G0033839
 protein coding gene Chr8:92673667-93041058 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033736
 protein coding gene Chr8:101628961-101998404 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034446
 protein coding gene Chr8:91523321-91889286 (+)
PWK/PhJ MGP_PWKPhJ_G0032651
 protein coding gene Chr8:87790530-88146053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032488
 protein coding gene Chr8:90397842-90748735 (+)
WSB/EiJ MGP_WSBEiJ_G0033061
 protein coding gene Chr8:91986415-92345197 (+)



Homology
more
  • Human Ortholog
    FTO, FTO alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FTO, FTO alpha-ketoglutarate dependent dioxygenase
  • Synonyms
    ALKBH9, BMIQ14, GDFD, IFEX9
  • Links
    NCBI Gene ID: 79068
    neXtProt AC: NX_Q9C0B1
    UniProt: Q9C0B1

  • Chr Location
    16q12.2; chr16:53701692-54158512 (+)  GRCh38
Human Diseases
more
  • Diseases
    13 with human FTO associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 10 alleles in 9 genetic backgrounds
    13 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    29
  • cDNA Data
    163
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055932 Ensembl Gene Model | MGI Sequence Detail 354915 C57BL/6J ±  kb
    transcript ENSMUST00000069718 Ensembl | MGI Sequence Detail 3564 Not Applicable  
    polypeptide ENSMUSP00000068380 Ensembl | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007694 alpha-ketoglutarate-dependent dioxygenase FTO
      (term hierarchy)
    • EC
      1.14.11.-, 1.14.11.53
    • InterPro Domains
      IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
      IPR032868 Alpha-ketoglutarate-dependent dioxygenase FTO
      IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
      IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
      IPR038413 FTO, C-terminal domain superfamily
    • GlyGen
      Q8BGW1 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 168
      Genomic 1
      cDNA 164
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142818
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 61
    • Earliest
      J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory