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Uggt1 Gene Detail
Summary
  • Symbol
    Uggt1
  • Name
    UDP-glucose glycoprotein glucosyltransferase 1
  • Synonyms
    0910001L17Rik, A930007H10Rik, C820010P03Rik, Ugcgl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443162
    NCBI Gene: 320011
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36179109-36283407 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3469 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443162
 protein coding gene Chr1:36179108-36283801 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015918
 protein coding gene Chr1:34642932-34751186 (-)
A/J MGP_AJ_G0015902
 protein coding gene Chr1:33725094-33831333 (-)
AKR/J MGP_AKRJ_G0015857
 protein coding gene Chr1:34209333-34316975 (-)
BALB/cJ MGP_BALBcJ_G0015856
 protein coding gene Chr1:33421681-33526818 (-)
C3H/HeJ MGP_C3HHeJ_G0015689
 protein coding gene Chr1:34394993-34500142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016309
 protein coding gene Chr1:36224100-36334266 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014031
 protein coding gene Chr1:30788460-30895832 (-)
CAST/EiJ MGP_CASTEiJ_G0015270
 protein coding gene Chr1:34276928-34385957 (-)
CBA/J MGP_CBAJ_G0015661
 protein coding gene Chr1:37154259-37279047 (-)
DBA/2J MGP_DBA2J_G0015762
 protein coding gene Chr1:33066092-33174652 (-)
FVB/NJ MGP_FVBNJ_G0015764
 protein coding gene Chr1:32583640-32690833 (-)
LP/J MGP_LPJ_G0015832
 protein coding gene Chr1:35015329-35126229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015784
 protein coding gene Chr1:39411144-39520843 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016356
 protein coding gene Chr1:34208504-34325508 (-)
PWK/PhJ MGP_PWKPhJ_G0015053
 protein coding gene Chr1:32807436-32912858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014835
 protein coding gene Chr1:34186390-34293896 (-)
WSB/EiJ MGP_WSBEiJ_G0015332
 protein coding gene Chr1:34182839-34287252 (-)



Homology
more
  • Human Ortholog
    UGGT1, UDP-glucose glycoprotein glucosyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGGT1, UDP-glucose glycoprotein glucosyltransferase 1
  • Synonyms
    HUGT1, UGCGL1, UGT1
  • Links
    NCBI Gene ID: 56886
    neXtProt AC: NX_Q9NYU2
    UniProt: Q9NYU2

  • Chr Location
    2q14.3; chr2:128091200-128195677 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous KO reduces susceptibility to and morbidity of RNA virus infection. Homozygous KO is embryonic lethal. The peptide is a folding sensor for glycoproteins in the ER.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    251
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320011 NCBI Gene Model | MGI Sequence Detail 104299 C57BL/6J ±  kb
    transcript NM_198899 RefSeq | MGI Sequence Detail 9045 C57BL/6  
    polypeptide Q6P5E4 UniProt | EBI | MGI Sequence Detail 1551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000017044 UDP-glucose:glycoprotein glucosyltransferase 1
      (term hierarchy)
    • EC
      2.4.1.-
    • InterPro Domains
      IPR040497 Glucosyltransferase 24, catalytic domain
      IPR029044 Nucleotide-diphospho-sugar transferases
      IPR009448 UDP-glucose:Glycoprotein Glucosyltransferase
      IPR040525 UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4
      IPR040693 UGGT, thioredoxin-like domain 1
      IPR040694 UGGT, thioredoxin-like domain 2
      IPR040692 UGGT, thioredoxin-like domain 3
    • GlyGen
      Q6P5E4 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 251
      cDNA 251

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915668, MGI:2138118, MGI:2138223, MGI:2138245
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory