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Mgat2 Gene Detail
Summary
  • Symbol
    Mgat2
  • Name
    mannoside acetylglucosaminyltransferase 2
  • Synonyms
    CDGS2, GNT2, GNT-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384966
    NCBI Gene: 217664
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69230931-69233544 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384966
 protein coding gene Chr12:69230931-69233547 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019788
 protein coding gene Chr12:68846559-68849172 (+)
A/J MGP_AJ_G0019746
 protein coding gene Chr12:66295672-66298285 (+)
AKR/J MGP_AKRJ_G0019722
 protein coding gene Chr12:68281716-68284330 (+)
BALB/cJ MGP_BALBcJ_G0019726
 protein coding gene Chr12:66757743-66760356 (+)
C3H/HeJ MGP_C3HHeJ_G0019532
 protein coding gene Chr12:68746944-68749557 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020178
 protein coding gene Chr12:71039693-71042306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017798
 protein coding gene Chr12:63840384-63842996 (+)
CAST/EiJ MGP_CASTEiJ_G0019083
 protein coding gene Chr12:63497163-63499776 (+)
CBA/J MGP_CBAJ_G0019501
 protein coding gene Chr12:73668350-73670963 (+)
DBA/2J MGP_DBA2J_G0019617
 protein coding gene Chr12:66212088-66214701 (+)
FVB/NJ MGP_FVBNJ_G0019604
 protein coding gene Chr12:65105516-65108130 (+)
LP/J MGP_LPJ_G0019689
 protein coding gene Chr12:68806369-68808982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019643
 protein coding gene Chr12:77020146-77022764 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020213
 protein coding gene Chr12:67746166-67748779 (+)
PWK/PhJ MGP_PWKPhJ_G0018848
 protein coding gene Chr12:60474105-60476718 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018643
 protein coding gene Chr12:62142918-62145523 (+)
WSB/EiJ MGP_WSBEiJ_G0019134
 protein coding gene Chr12:68364847-68367460 (+)



Homology
more
  • Human Ortholog
    MGAT2, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGAT2, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
  • Synonyms
    CDG2A, CDGS2, GLCNACTII, GNT2, GNT-II
  • Links
    NCBI Gene ID: 4247
    neXtProt AC: NX_Q10469
    UniProt: Q10469

  • Chr Location
    14q21.3; chr14:49620799-49623481 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mgat2 mouse models; 1 with human MGAT2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice recapitulate aspects of the phenotype exhibited by patients with congenital disorders of glycosylation (CDG), particularly type IIa. Most null mice died either embyronically or postnataly and exhibited muscular, gastrointestinal, hematologic, and osteogenic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    103
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043998 Ensembl Gene Model | MGI Sequence Detail 2614 C57BL/6J ±  kb
    transcript ENSMUST00000060579 Ensembl | MGI Sequence Detail 2614 Not Applicable  
    polypeptide ENSMUSP00000057905 Ensembl | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010379 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
      (term hierarchy)
    • EC
      2.4.1.143
    • InterPro Domains
      IPR007754 N-acetylglucosaminyltransferase II
      IPR029044 Nucleotide-diphospho-sugar transferases
    • GlyGen
      Q921V5 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144720
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:80661 Wang Y, et al., Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec;11(12):1051-70
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory