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Alg1 Gene Detail
Summary
  • Symbol
    Alg1
  • Name
    ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
  • Synonyms
    HMAT1, HMT1, MGC:18946
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384774
    NCBI Gene: 208211
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:5051485-5062776 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384774
 protein coding gene Chr16:5051410-5062776 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022488
 protein coding gene Chr16:1763421-1774712 (+)
A/J MGP_AJ_G0022450
 protein coding gene Chr16:1573541-1584829 (+)
AKR/J MGP_AKRJ_G0022427
 protein coding gene Chr16:1762939-1774223 (+)
BALB/cJ MGP_BALBcJ_G0022455
 protein coding gene Chr16:1720860-1732145 (+)
C3H/HeJ MGP_C3HHeJ_G0022222
 protein coding gene Chr16:1792736-1804569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022904
 protein coding gene Chr16:1850816-1862109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020425
 protein coding gene Chr16:1511783-1522891 (+)
CAST/EiJ MGP_CASTEiJ_G0021748
 protein coding gene Chr16:1798820-1811529 (+)
CBA/J MGP_CBAJ_G0022191
 protein coding gene Chr16:1955234-1966515 (+)
DBA/2J MGP_DBA2J_G0022322
 protein coding gene Chr16:1664058-1675339 (+)
FVB/NJ MGP_FVBNJ_G0022297
 protein coding gene Chr16:1665373-1676852 (+)
LP/J MGP_LPJ_G0022390
 protein coding gene Chr16:1756737-1768570 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022319
 protein coding gene Chr16:1797108-1808307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022916
 protein coding gene Chr16:1735266-1746547 (+)
PWK/PhJ MGP_PWKPhJ_G0021488
 protein coding gene Chr16:1756126-1767424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021319
 protein coding gene Chr16:1831143-1842361 (+)
WSB/EiJ MGP_WSBEiJ_G0021797
 protein coding gene Chr16:1768499-1779795 (+)



Homology
more
  • Human Ortholog
    ALG1, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALG1, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
  • Synonyms
    CDG1K, hMat-1, HMAT1, HMT-1, HMT1, Mat-1, MT-1
  • Links
    NCBI Gene ID: 56052
    neXtProt AC: NX_Q9BT22
    UniProt: Q9BT22

  • Chr Location
    16p13.3; chr16:5033702-5087379 (+)  GRCh38
  • Human Ortholog
    ALG1L1P, ALG1 like 1, pseudogene
  • Synonyms
    ALG1L, ALG1L1
  • Links
    NCBI Gene ID: 200810

  • Chr Location
    3q21.2; chr3:125929272-125990537 (-)  GRCh38
  • Human Ortholog
    ALG1L2, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2
  • Links
    NCBI Gene ID: 644974
    neXtProt AC: NX_C9J202
    UniProt: C9J202

  • Chr Location
    3q22.1; chr3:130081831-130113227 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039427 Ensembl Gene Model | MGI Sequence Detail 11292 C57BL/6J ±  kb
transcript ENSMUST00000100196 Ensembl | MGI Sequence Detail 1755 Not Applicable  
polypeptide ENSMUSP00000097770 Ensembl | MGI Sequence Detail 482 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory