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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gnas
GNAS complex locus
MGI:95777
210 phenotypes from 18 alleles in 32 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gnas/Nespastm1.1Jop/Gnas+
involves: 129S1/Sv * M. spretus 		abnormal DNA methylation J:171195
Gnas/Nespastm1.1Jop/Gnas+
involves: 129S/SvEv * 129S1/Sv 		abnormal DNA methylation J:171195
Gnas/Nespastm2.1Jop/Gnas+
involves: 129S/SvEv * 129S1/Sv 		abnormal DNA methylation J:171195
GnasOedsml/Gnas+
involves: 101/H * C3H/HeH 		abnormal coat appearance J:65007
abnormal imprinting J:65007
abnormal inflammatory response J:65007
decreased body weight J:65007
hydrops fetalis J:65007
increased brown adipose tissue amount J:65007
postnatal growth retardation J:65007
postnatal lethality, complete penetrance J:65007
prenatal lethality, incomplete penetrance J:65007
respiratory distress J:65007
small heart J:65007
GnasOedsml/Gnas+
involves: 101/H * C3H/HeH * M. m. castaneus 		hydrops fetalis J:65007
postnatal lethality, complete penetrance J:65007
GnasOedsml/Gnas+
Not Specified 		decreased birth body size J:91717
decreased circulating calcium level J:91717
decreased heart weight J:91717
edema J:91717
increased circulating parathyroid hormone level J:91717
increased circulating phosphate level J:91717
GnasOedsml/GnasOedsml
involves: 101/H * C3H/HeH 		prenatal lethality, complete penetrance J:65007
GnasOedsml/Gnastm1Jop
involves: 129S/SvEv * C57BL/6 		abnormal heart size J:91717
normal homeostasis/metabolism phenotype J:91717
Gnastm1.1Plag/Gnas+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL 		neonatal lethality, incomplete penetrance J:184320
Gnastm1.1Plag/Gnas+
involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL 		neonatal lethality, incomplete penetrance J:184320
Gnastm1.2Plag/Gnas+
involves: 129S4/SvJae * BALB/cJ * C57BL/6 * CD-1 * SJL 		neonatal lethality, incomplete penetrance J:184320
Gnastm1Gwa/Gnas+
either: (involves: 129S4/SvJae * 129/Sv) or (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * CD-1) 		decreased alcohol consumption J:70175
Gnastm1Gwa/Gnas+
involves: 129S4/SvJae * C57BL/6J 		abnormal enzyme/coenzyme activity J:70175
impaired righting response J:70175
Gnastm1Gwa/Gnas+
involves: 129S/SvEv * 129S4/SvJae 		abnormal hypodermis morphology J:174525
ectopic bone J:174525
obese J:174525
skin lesions J:174525
Gnastm1Jop/Gnas+
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:91717
Gnastm1Kel/Gnas+
involves: 129S2/SvPas 		increased circulating ghrelin level J:184320
Gnastm1Kel/Gnas+
involves: 129S2/SvPas * C57BL/6J 		abnormal imprinting J:91703
abnormal suckling behavior J:91703
decreased brown adipose tissue amount J:91703
decreased circulating glucagon level J:91703
decreased circulating glucose level J:91703
decreased circulating insulin level J:91703
decreased interscapular fat pad weight J:91703
decreased locomotor activity J:91703
decreased white adipose tissue amount J:91703
postnatal lethality, complete penetrance J:91703
slow postnatal weight gain J:91703
weakness J:91703
Gnastm1Kel/Gnas+
involves: 129S2/SvPas * C57BL/6J * CD-1 		postnatal lethality J:91703
Gnastm1Lsw/Gnas+
involves: 129S4/SvJae 		decreased urine osmolality J:56867
Gnastm1Lsw/Gnas+
involves: 129S4/SvJae * CD-1 		abnormal blood homeostasis J:106729
abnormal body size J:60971
abnormal brown adipose tissue morphology J:60971
abnormal cerebellar cortex morphology J:49340
abnormal gas homeostasis J:60971
abnormal glucose homeostasis J:106729
abnormal motor capabilities/coordination/movement J:49340
abnormal outer ear morphology J:49340
abnormal posture J:49340
abnormal skin morphology J:49340
absent gastric milk in neonates J:49340
ataxia J:49340
decreased birth body size J:49340
decreased birth weight J:49340
decreased body length J:60971
decreased body mass index J:60971
decreased body weight J:60971
decreased brown adipose tissue amount J:60971
decreased circulating calcium level J:49340
decreased circulating cholesterol level J:60971
decreased circulating glucose level J:106729
decreased circulating insulin level J:106729
decreased circulating triglyceride level J:60971
decreased epididymal fat pad weight J:60971
decreased interscapular fat pad weight J:60971
decreased locomotor activity J:60971
decreased oxygen consumption J:60971
decreased survivor rate J:49340
decreased urine noradrenaline level J:60971
decreased white adipose tissue amount J:60971
delayed kidney development J:49340
genetic imprinting J:49340
normal homeostasis/metabolism phenotype J:60971
impaired balance J:49340
impaired righting response J:49340
improved glucose tolerance J:106729
increased birth body size J:49340
increased birth weight J:49340
increased body mass index J:60971
increased brown adipose tissue amount J:60971
increased brown fat cell lipid droplet size J:60971
increased circulating parathyroid hormone level J:49340
increased insulin sensitivity J:106729
increased interscapular fat pad weight J:60971
increased lean body mass J:49340
increased locomotor activity J:60971
increased muscle cell glucose uptake J:106729
increased oxygen consumption J:60971
increased urine dopamine level J:60971
increased urine noradrenaline level J:60971
increased white adipose tissue amount J:60971
insensitivity to parathyroid hormone J:49340
neonatal lethality, incomplete penetrance J:49340
no spontaneous movement J:49340
obese J:49340
postnatal growth retardation J:49340, J:60971
postnatal lethality, incomplete penetrance J:49340
skin edema J:49340
thymus cortex atrophy J:49340
tremors J:49340
Gnastm1Lsw/Gnastm1Lsw
involves: 129S4/SvJae * CD-1 		prenatal lethality, complete penetrance J:49340
Gnastm2.1Lsw/Gnas+
involves: 129S6/SvEvTac * Black Swiss 		abnormal response/metabolism to endogenous compounds J:97229
decreased circulating parathyroid hormone level J:97229
decreased circulating phosphate level J:97229
maternal imprinting J:97229
Gnastm2.1Lsw/Gnastm2.1Lsw
involves: 129S6/SvEvTac * CD-1 * FVB/N 		normal cellular phenotype J:89923
Gnastm2Jop/Gnas+
involves: 129S/SvEv 		abnormal gas homeostasis J:182868
normal behavior/neurological phenotype J:182868
decreased birth weight J:182868
decreased body length J:182868
decreased bone mineral density J:182868
decreased circulating leptin level J:182868
decreased lean body mass J:182868
decreased percent body fat/body weight J:182868
decreased total body fat amount J:182868
increased basal metabolism J:182868
increased carbon dioxide production J:182868
increased food intake J:182868
increased oxygen consumption J:182868
postnatal lethality, incomplete penetrance J:182868
short femur J:182868
slow postnatal weight gain J:182868
Gnastm2Kel/Gnas+
either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) 		abnormal response to new environment J:97634
hyperactivity J:97634
normal nervous system phenotype J:97634
paternal imprinting J:97634
Gnastm3Jop/Gnas+
involves: 129S/SvEv 		abnormal eating behavior J:182868
normal behavior/neurological phenotype J:182868
decreased birth weight J:182868
decreased lean body mass J:182868
decreased total body fat amount J:182868
postnatal lethality, incomplete penetrance J:182868
slow postnatal weight gain J:182868
Gnastm3Kel/Gnas+
involves: 129P2/OlaHsd * C57BL/6J * DS/2 		abnormal body weight J:143477
abnormal fat pad morphology J:143477
abnormal imprinting J:143477
paternal imprinting J:143477
postnatal lethality, incomplete penetrance J:143477
Gnastm3Lsw/Gnastm3Lsw
Ren1tm2(cre)Gom/Ren1+
involves: 129S6/SvEvTac * Black Swiss 		abnormal kidney physiology J:118076
abnormal renin activity J:118076
decreased circulating aldosterone level J:118076
decreased circulating renin level J:118076
decreased mean systemic arterial blood pressure J:118076
decreased renal glomerular filtration rate J:118076
decreased urine osmolality J:118076
increased urine prostaglandin level J:118076
Gnastm3Lsw/Gnastm3Lsw
Tg(Col2a1-cre)1Rsjo/0
involves: 129S6/SvEvTac * FVB/N 		abnormal cartilage development J:97230
abnormal long bone epiphyseal plate morphology J:97230
abnormal long bone epiphyseal plate proliferative zone J:97230
abnormal long bone epiphysis morphology J:97230
abnormal pulmonary alveolus morphology J:97230
abnormal tibia morphology J:97230
cyanosis J:97230
domed cranium J:97230
neonatal lethality, complete penetrance J:97230
short limbs J:97230
Gnastm3Lsw/Gnastm3Lsw
Tg(TPO-cre)1Shk/0
involves: 129S6/SvEvTac * FVB/NCr 		normal endocrine/exocrine gland phenotype J:168249
Gnastm4Lsw/Gnas+
involves: 129S6/SvEvTac 		abnormal blood homeostasis J:233851
abnormal kidney morphology J:233851
Gnastm4Lsw/Gnas+
involves: 129S6/SvEvTac * Black Swiss * CD-1 		abnormal adipose tissue morphology J:99237
abnormal glucose homeostasis J:99237
decreased oxygen consumption J:99237
edema J:99237
impaired glucose tolerance J:99237
increased brown adipose tissue amount J:99237
increased circulating glucose level J:99237
increased circulating insulin level J:99237
increased circulating leptin level J:99237
increased circulating triglyceride level J:99237
increased interscapular fat pad weight J:99237
increased total body fat amount J:99237
increased white adipose tissue amount J:99237
insulin resistance J:99237
obese J:99237
paternal imprinting J:99237
postnatal lethality, incomplete penetrance J:99237
Gnastm4Lsw/Gnastm4Lsw
involves: 129S6/SvEvTac * Black Swiss * CD-1 		prenatal lethality J:99237
Gnastm5.1Lsw/Gnastm5.1Lsw
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal bone ossification J:254756
abnormal craniofacial bone morphology J:254756
abnormal craniofacial morphology J:254756
abnormal hyoid bone body morphology J:254756
abnormal hyoid bone morphology J:254756
abnormal incisor morphology J:254756
abnormal mandible morphology J:254756
abnormal maxilla morphology J:254756
abnormal nasal septum cartilage morphology J:254756
abnormal premaxilla morphology J:254756
abnormal suckling behavior J:254756
abnormal sympathetic ganglion morphology J:254756
abnormal thyroid cartilage morphology J:254756
abnormal tongue morphology J:254756
abnormal tympanic ring morphology J:254756
absent mandibular angle J:254756
absent mandibular condyloid process J:254756
absent mandibular coronoid process J:254756
absent nasal capsule J:254756
normal cardiovascular system phenotype J:254756
complete cleft palate J:254756
cyanosis J:254756
domed cranium J:254756
normal embryo phenotype J:254756
mandible hypoplasia J:254756
maxilla hypoplasia J:254756
neonatal lethality, complete penetrance J:254756
normal nervous system phenotype J:254756
ocular hypertelorism J:254756
palatal shelves fail to meet at midline J:254756
palate bone hypoplasia J:254756
premature bone ossification J:254756
premature metopic suture closure J:254756
protruding tongue J:254756
respiratory distress J:254756
round face J:254756
short mandible J:254756
short maxilla J:254756
short snout J:254756
small dorsal root ganglion J:254756
Gnastm5.1Lsw/Gnastm5.1Lsw
Tg(Alb1-cre)1Dlr/?
involves: 129S6/SvEvTac * Black Swiss * FVB/N 		abnormal energy expenditure J:102504
decreased circulating insulin level J:102504
decreased total body fat amount J:102504
normal homeostasis/metabolism phenotype J:102504
hypoglycemia J:102504
improved glucose tolerance J:102504
increased circulating glucagon level J:102504
increased circulating triglyceride level J:102504
increased liver glycogen level J:102504
increased liver weight J:102504
increased pancreas weight J:102504
pancreatic islet hyperplasia J:102504
Gnastm5.1Lsw/Gnastm5.1Lsw
Tg(Fabp4-cre)1Abel/0
involves: FVB 		abnormal adipose tissue development J:159612
abnormal urine catecholamine level J:159612
abnormal white adipose tissue physiology J:159612
decreased body fat mass J:159612
decreased body length J:159612
decreased body size J:159612
decreased body weight J:159612
decreased circulating free fatty acids level J:159612
decreased circulating insulin level J:159612
decreased circulating leptin level J:159612
decreased circulating triglyceride level J:159612
decreased epididymal fat pad weight J:159612
decreased inguinal fat pad weight J:159612
decreased liver triglyceride level J:159612
decreased locomotor activity J:159612
decreased mesenteric fat pad weight J:159612
decreased renal fat pad weight J:159612
decreased skeletal muscle triglyceride level J:159612
decreased subcutaneous adipose tissue amount J:159612
decreased susceptibility to diet-induced obesity J:159612
decreased white adipose tissue amount J:159612
decreased white fat cell size J:159612
normal homeostasis/metabolism phenotype J:159612
hypoglycemia J:159612
impaired adaptive thermogenesis J:159612
improved glucose tolerance J:159612
increased circulating corticosterone level J:159612
increased energy expenditure J:159612
increased fatty acid oxidation J:159612
increased insulin sensitivity J:159612
increased lean body mass J:159612
premature death J:159612
Gnastm5.1Lsw/Gnastm5.1Lsw
Tg(Gfy-cre)1Yyos/?
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N 		normal taste/olfaction phenotype J:233447
Gnastm5.1Lsw/Gnastm5.1Lsw
Tg(Nes-cre)1Atp/0
involves: 129S6/SvEvTac * FVB/N 		normal craniofacial phenotype J:254756
Gnastm5.1Lsw/Gnastm5.1Lsw
Tg(Slc5a2-cre)1Tauc/0
involves: C57BL/6 * DBA/2 		abnormal blood homeostasis J:233851
abnormal urine homeostasis J:233851
decreased circulating calcium level J:233851
decreased vitamin D level J:233851
increased circulating parathyroid hormone level J:233851
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-Gnas)1593Mpke/0
B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-Gnas)1593Mpke 		abnormal dorsal striatum morphology J:166114
abnormal spatial learning J:166114
abnormal ventral striatum morphology J:166114
normal behavior/neurological phenotype J:166114
decreased prepulse inhibition J:166114
enhanced long-term potentiation J:166114
enhanced paired-pulse facilitation J:166114
enlarged lateral ventricles J:166114
hyperactivity J:166114
impaired contextual conditioning behavior J:166114
impaired spatial working memory J:166114
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory