Acan Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acan
aggrecan
MGI:99602

57 phenotypes from 10 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acan^b2b183Clo/Acan^b2b183Clo C57BL/6J-Acan^b2b183Clo	brachypodia	J:175213
	cardiac hypertrophy	J:175213
	cardiomyopathy	J:175213
	cleft palate	J:175213
	disproportionate dwarf	J:175213
Acan^cmd-Bc/Acan^cmd-Bc BALB/cGaBc-Acan^cmd-Bc	abnormal limb development	J:58755
	cleft palate	J:58755
	distended abdomen	J:58755
	neonatal lethality, complete penetrance	J:65316
	protruding tongue	J:58755
	pulmonary hypoplasia	J:65316
	respiratory failure	J:65316
	short limbs	J:65316
	short snout	J:58755
	small thoracic cavity	J:65316
Acan^cmd/Acan⁺ involves: STOCK T t^low Itpr3^tf	abnormal gait	J:41498
	abnormal intervertebral disk morphology	J:41498
	abnormal spinal cord morphology	J:41498
	abnormal vertebral body morphology	J:41498
	aphagia	J:41498
	disproportionate dwarf	J:41498
	intervertebral disk degeneration	J:41498
	kyphosis	J:41498
	lordosis	J:41498
	premature death	J:41498
Acan^cmd/Acan^cmd involves: STOCK T t^low Itpr3^tf	abnormal cartilage development	J:1535
	abnormal cochlear IHC afferent innervation pattern	J:553
	abnormal cochlear inner hair cell morphology	J:553
	abnormal lung morphology	J:23353
	abnormal organ of Corti morphology	J:553
	absent cochlear outer hair cells	J:553
	cleft palate	J:553
	deafness	J:553
	disproportionate dwarf	J:553
	increased or absent threshold for auditory brainstem response	J:553
	neonatal lethality, complete penetrance	J:553
	polyhydramnios	J:23353
	pulmonary hypoplasia	J:23353
	small thoracic cavity	J:23353
Acan^cmd/Acan^cmd STOCK T t^low Itpr3^tf	abnormal cartilage development	J:30795
	abnormal chondrocyte morphology	J:5952, J:30795
	abnormal craniofacial bone morphology	J:30795
	abnormal limb morphology	J:30795
	abnormal liver morphology	J:5952
	abnormal rib morphology	J:30795
	abnormal trabecular bone morphology	J:30795
	abnormal tracheal cartilage morphology	J:5952
	abnormal vertebrae morphology	J:5952, J:30795
	absent caudal vertebrae	J:30795
	brachydactyly	J:30795
	cleft palate	J:5952, J:30795
	decreased length of long bones	J:5952
	disproportionate dwarf	J:30795
	distended abdomen	J:5952, J:30795
	enlarged liver	J:5952
	flattened snout	J:5952
	neonatal lethality, complete penetrance	J:5952
	protruding tongue	J:5952
	respiratory distress	J:5952
	short basicranium	J:30795
	short femur	J:5952
	short humerus	J:5952
	short snout	J:5952
	short vertebral column	J:5952, J:30795
Acan^m1Btlr/Acan⁺ C57BL/6J-Acan^m1Btlr/Btlr	short femur	J:309727
Acan^m1Btlr/Acan⁺ C57BL/6J-Acan^m1Btlr/Btlr	short tibia	J:309727
Acan^m2Btlr/Acan⁺ C57BL/6J-Acan^m2Btlr/Btlr	short femur	J:309727
Acan^m2Btlr/Acan⁺ C57BL/6J-Acan^m2Btlr/Btlr	short tibia	J:309727
Acan^m2Btlr/Acan^m2Btlr C57BL/6J-Acan^m2Btlr/Btlr	short femur	J:309727
Acan^m2Btlr/Acan^m2Btlr C57BL/6J-Acan^m2Btlr/Btlr	short tibia	J:309727
Acan^mpc227H/Acan^mpc227H involves: BALB/c * C3H/HeH * C57BL/6J	abnormal joint morphology	J:234901
	obese	J:234901
Acan^{tm1(cre/ERT2)Crm}/Acan^{tm1(cre/ERT2)Crm} involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:155982
Acan^tm1Afos/Acan^tm1Afos involves: C57BL/6	no abnormal phenotype detected	J:97622
Acan^{tm1b(EUCOMM)Hmgu}/Acan⁺ C57BL/6N-Acan^{tm1b(EUCOMM)Hmgu}/H	increased basophil cell number	J:211773
Acan^{tm1b(EUCOMM)Hmgu}/Acan^{tm1b(EUCOMM)Hmgu} C57BL/6N-Acan^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Acan^tm2Afos/Acan^tm2Afos involves: C57BL/6	decreased susceptibility to induced arthritis	J:122102

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