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Allele Information
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Allele:
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Tg(Nes-cre)1Kln
transgene insertion 1, Rudiger Klein
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Driver: Nes
Type: Transgenic
(Recombinase)
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Synonym:
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n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
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Molecular description:
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This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion.
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Find mice (IMSR):
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Mouse Strains:
4
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Nes-cre)1Kln activity also observed in:
adipose tissue,
alimentary system,
cardiovascular system,
cavities & their linings,
endocrine system,
head,
hemolymphoid system,
integumental system,
liver & biliary system,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs
(less)
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Tissue Information
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Mesenchyme
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Other recombinase alleles with activity in Mesenchyme tissues:
7630403G23RikTg(Th-cre)1Tmd,
Acanem2(dre)Smoc,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Alx3em1(cre/ERT2)Lanyu,
Amhr2tm3(cre)Bhr,
Atoh8tm1(EGFP/cre)Gasa,
Bmp7tm6(cre)Rob,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cfap126tm1.1(icre)Heli,
Cldn6tm1(cre/ERT2)Dam,
Col10a1tm2.1(cre)Ksec,
Crhtm1(cre)Zjh,
Ddx4em1(icre)Jobo,
Dmbx1tm3(cre)Aoh,
E2f1Tg(Wnt1-cre)2Sor,
Edil3Tg(Sox2-cre)1Amc,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
Eomestm4.1(icre)Rob,
Fgf18tm2.2(cre/ERT2)Dor,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxa2tm3.1(icre)Heli,
Foxd1tm1(GFP/cre)Amc,
Foxg1tm1(cre)Skm,
Gad2tm2(cre)Zjh,
Gli1tm3(cre/ERT2)Alj,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sortm1(FLP1)Dym,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hand2em1(dre)Pjen,
HhatTg(TFAP2A-cre)1Will,
Hlfem1(cre/ERT2)Smoc,
Hlfem2(cre/ERT2)Suda,
Hnf4atm1(cre)Sdv,
Hoxa3tm1(cre)Moon,
Hoxb1tm1(cre)Og,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Krt19tm1(cre)Mmt,
Lgr6tm2.1(cre/ERT2)Cle,
Lhx1tm1.1(icre)Rob,
Lmx1btm2(cre/ERT2)Rjo,
Ltftm1(icre)Tdku,
Mecomem1(cre/ERT2)Suda,
Mecomtm4.1(cre/ERT2)Aspe,
Megf6em3(cre)Zzhg,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Nkx1-2tm2296.1(cre/ERT2)Arte,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm1(cre)Wez,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Npr3em1(cre/ERT2)Bzsh,
Nrg1em2(cre/ERT2)Bzsh,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pax9tm1.1(cre)Sbam,
Pdgfctm2.1(cre/ERT2)Hdin,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm1.1(flpo)Leol,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Sall4tm1.1(EGFP/cre/ERT2)Ykawa,
Scxtm1.1(cre)Shuk,
Shhtm1(EGFP/cre)Cjt,
Shroom3Gt(ROSA53)Sor,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Smoc2tm1(cre/ERT2)Cle,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx1tm1.1(cre/ERT2)Zzhg,
Tbx5tm1.1(cre/ERT2)Bbr,
Tg(Acan-cre/ERT2,-luc)1Gbg,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(ACTC1-cre)1Miwa,
Tg(Adipoq-cre)1Evdr,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)#Ykub,
Tg(Cdx1-cre)23Kem,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(Cited1-cre/ERT2,-EGFP)1Mdca,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1And,
Tg(Col10a1-cre)1465Vdm,
Tg(Col10a1-cre)1466Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col10a1-cre)#Ksec,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp39a1-cre)1Aibs,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre/ERT2)#Mpac,
Tg(Dll1-cre)1Gos,
Tg(Dll1-cre)33Dchp,
Tg(Dll4-cre)#Xia,
Tg(dlx5a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Etv2-cre)15508Djg,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Fev-cre)FF9Pasq,
Tg(Foxa3-cre)1Khk,
Tg(Foxl1-cre)1Khk,
Tg(Frzb-cre)1Tylz,
Tg(GATA5-cre)1Krc,
Tg(Gdf5-cre,-ALPP)1Kng,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hand2-cre)7-1Clou,
Tg(Hes7-cre)1Kag,
Tg(Hoxa2-cre)1Dym,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mnx1-cre/ERT2)8Rbro,
Tg(Mpz-cre)1Brn,
Tg(Mpz-cre)94Imeg,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh6-cre)2182Mds,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Wmz,
Tg(Nkx2-1-cre)2Sand,
Tg(NKX2-5-cre)#Kyuhl,
Tg(NKX2-5*-cre)#Kyuhl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Nrp2-cre/ERT2,-Kikume)1Qsch,
Tg(Osr1-cre)4Mrt,
Tg(Pax2-cre)10Shwl,
Tg(Pax3-cre)1Joe,
Tg(Pax3-cre)2Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(POU3F4-cre)M51Cren,
Tg(Pou4f3-cre)1Devet,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Mpac,
Tg(Prg4-cre)#Mkaz,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Rr437-cre)#Hmd,
Tg(Rr456-cre/Esr1*)7Hmd,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(Rxfp2-cre)1Aia,
Tg(Rxfp2-cre)5Aia,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Six1-cre)2Kwk,
Tg(Smad7-cre)1Sjc,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Sox10-cre)507Mcln,
Tg(Sox10-ERT2/cre/ERT2)17Sor,
Tg(Sox10-icre/ERT2)388Wdr,
Tg(Sox2-flpo)#Mhem,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Stab2-icre)1.2Cger,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx1-cre)1Joe,
Tg(Tbx4-cre)6Kras,
Tg(Tbx4-cre/ERT2)#Kras,
Tg(Tbx6-cre)#Rsam,
Tg(T-cre)1Gos,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Ymor,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(Wnt1-cre/ERT)1Alj,
Tg(Wt1-cre)1Jbeb,
Tg(Wt1-cre)#Jbeb,
Ttm1(cre/ERT2)Hssk,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor,
Vimem1(cre/ERT2)Bzsh,
Wnt6tm1(cre)Mrc,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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Recombinase Activity
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References
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