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Tg(Nes-cre)1Kln - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-cre)1Kln
transgene insertion 1, Rudiger Klein 		Driver: Nes
Type: Transgenic (Recombinase)
Synonym: n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
Molecular description: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion.
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-cre)1Kln activity also observed in:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1395 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory