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Tg(Ins2-cre)25Mgn - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ins2-cre)25Mgn
transgene insertion 25, Mark A Magnuson 		Driver: Ins2
Type: Transgenic (Recombinase)
Synonym: Ins2cre, Ins-Cre, M line, RIP2-cre, RIP2Cre, Rip-cre, [RIP]-Cre, RIP Cre, RIP-Cre, RIPCre, TgN(ins2-Cre)25Mgn
Molecular description: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ins2-cre)25Mgn activity also observed in:
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
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J:193672 Full Image
Fig. EIIa Pancreas P56 J:193672 Full image
Fig. Ins2 Embryo 2 E15.5 J:193672 Full image
Fig. Ins2 Embryo 3 E10.5 J:193672 Fig. Ins2 Embryo 3 E15.5 J:193672 Full image
Fig. Ins2 Embryo 5 E10.5 J:193672 Full Image
Fig. Ins2 Pancreas P7 J:51826 Fig. 4 J:69314 Fig. 1
J:69314 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 292 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory