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Tg(GFAP-cre)25Mes - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(GFAP-cre)25Mes
transgene insertion 25, Albee Messing 		Driver: GFAP
Type: Transgenic (Recombinase)
Synonym: Gfa2-Cre, GFAP-Cre, GFAP-Cre-m, hGFAP-cre, hGFAPcre, hGFAP::Cre, Tg95.2, TgN25Mes, TgN(GFAPcre)25Mes
Molecular description: This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(GFAP-cre)25Mes activity also observed in:
Tissue Information
Liver & Biliary System Other recombinase alleles with activity in Liver & Biliary System tissues:
Images
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J:184578 Full Image
Fig. GFAP Liver P56 J:184578 Full Image
Fig. GFAP Liver P7 J:72509 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 421 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory