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Olig1tm1(cre)Rth - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Olig1tm1(cre)Rth
oligodendrocyte transcription factor 1; targeted mutation 1, David H Rowitch 		Driver: Olig1
Type: Targeted (Null/knockout, Recombinase)
Synonym: CreOlig1 Tg, Olig1-, Olig1-cre, OLIG1cre, Olig1-null;PGKneo, Olig1tm1Rth
Molecular description: The majority of the coding region for this gene was replaced with a cre-neo cassette via homologous recombination so that the cre coding sequence is joined in-frame to the endogenous gene's coding region immediately following the translation initiation site. In situ hybridization of spinal cord from homozygous mutant embryos did not detect transcripts from the endogenous gene. In spinal cord from E10.5-E12.5 embryos heterozygous for this allele and for the conditional (Cre recombinase activated) lacZ reporter allele Gt(ROSA)26Sortm1Sor, Xgal staining co-localized with in situ hybridizing mRNAs for motor neuron and oligodendrocyte markers; antibodies to beta-galactosidase co-localized with those to an oligodendrocyte marker, but not to an astrocyte marker.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Olig1tm1(cre)Rth activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 87 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory