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Allele Information
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Allele:
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Hprt1tm1(CAG-cre)Mnn
hypoxanthine phosphoribosyltransferase 1;
targeted mutation 1, Jeffrey R Mann
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Driver: CAG
Type: Targeted
(Recombinase)
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Synonym:
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Hprt1tm1(cre)Mnn, hprt-cre, Hprtcre, Hprttm1(CAG.cre)MdCoh
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Molecular description:
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An expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted following the cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences.
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Find mice (IMSR):
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Mouse Strains:
1
strain available
Cell Lines:
0 lines available
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Additional Tissues:
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Hprt1tm1(CAG-cre)Mnn activity also observed in:
alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
head,
hemolymphoid system,
integumental system,
liver & biliary system,
mesenchyme,
mouse-other,
muscle,
nervous system,
renal & urinary system,
respiratory system,
skeletal system
(less)
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Tissue Information
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Reproductive System
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Other recombinase alleles with activity in Reproductive System tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Agrptm1(cre)Lowl,
Alpltm1(cre)Nagy,
Amhr2em1(icre)Fjd,
Amhr2tm3(cre)Bhr,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cd19tm1(cre)Cgn,
Cdh5em1(cre/ERT2)Boz,
Cdkn2atm3(cre)Cjs,
Chattm2(cre)Lowl,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Corttm1(cre)Zjh,
Crhtm1(cre)Zjh,
Ctsktm1(cre)Ska,
Cx3cr1tm2.1(cre/ERT2)Litt,
Cyp11a1tm1(GFP/cre)Pzg,
Ddx4em1(cre/ERT2)Utr,
Ddx4em1(icre)Jobo,
Ddx4tm1.1(cre)Dcp,
Dlx5tm1(cre/ERT2)Zjh,
Dmp1tm1(cre)Msue,
Dmp1tm2(EGFP/cre/ERT2)Wtsi,
Dpep3tm1(EGFP/cre/ERT2)Wtsi,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Elf5em1(cre)Jilu,
En1tm2(cre)Wrst,
Foxd1tm1(GFP/cre)Amc,
Foxj1tm1.1(cre/ERT2/GFP)Htg,
Foxl2tm1.1(cre/ERT2)Kliu,
Foxl2tm1(GFP/cre/ERT2)Pzg,
Gad2tm2(cre)Zjh,
Gfra1tm4.1(cre/ERT2)Jmi,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sortm1.1(Acrv1-icre)Jcoc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Nat,
Gt(ROSA)26Sortm1(FLP1)Dym,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
H2az2Tg(Wnt1-cre)11Rth,
HhatTg(TFAP2A-cre)1Will,
Hic1tm2.1(cre/ERT2)Tmun,
Hnf4atm1(cre)Sdv,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Hsd11b2tm1(cre)Anft,
Id4tm1(cre)Bcgen,
Ifi208Tg(Cspg4-cre)1Akik,
Igfbp5tm1(icre/ERT2)Murr,
Ihhem1(Tomm20/mKate2,dre)Xya,
Itga8tm1.1(cre/ERT2)Jomm,
Kittm1.1(cre)Jmol,
Kittm2.1(cre/Esr1*)Jmol,
Krt17tm1(cre)Murr,
Krt19tm1(cre)Mmt,
Krt4em1(cre/ERT2)Bcgen,
Krt7tm1(cre/ERT2)Que,
Lcn9em1(cre)Xys,
Leprtm2(cre)Rck,
Lgr5tm1(cre/ERT2)Cle,
Lhx9tm1.1(cre/ERT2)Gan,
Ltftm1(cre)Stw,
Ltftm1(icre)Tdku,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mapttm1(cre)Nagy,
Mecomtm4.1(cre/ERT2)Aspe,
Mnx1tm4(cre)Tmj,
Ms4a3em2(cre)Fgnx,
Myf5tm3(cre)Sor,
Nanos2em2(cre)Jahe,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx3-1tm4(cre/ERT2)Mms,
Npvftm1.1(icre)Gand,
Omptm4(cre)Mom,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Oxtrtm3.1(Oxtr*,cre)Knis,
Pax3tm1(cre)Joe,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pgrtm2(cre)Lyd,
Plekha5Tg(AMH-cre)1Flor,
Plvaptm1.1(cre/ERT2)Tng,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Prlrtm1.1(cre)Uboe,
Prss29em1(cre/EGFP)Tesp,
Pscaem1(cre/ERT2)Smoc,
Pvalbtm1.1(cre)Aibs,
Pvalbtm1(cre)Arbr,
Rtel1tm4.1(cre/ERT2)Hdin,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Sall4tm1.1(EGFP/cre/ERT2)Ykawa,
Shhtm1(EGFP/cre)Cjt,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Sohlh1tm1.1(cre/ERT2)Kliu,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Stra8tm1(EGFP/cre/ERT2)Wtsi,
Taglntm2(cre)Yec,
Tas2r131tm2.1(cre)Uboe,
Tcf21em1(cre/ERT2)Boz,
Tg(Abpa-cre)1Cmal,
Tg(ACTA1-cre)79Jme,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(Acta2-cre/ERT2)#Pcn,
Tg(ACTB-cre)1Tes,
Tg(ACTFLPe)9205Dym,
Tg(Adipoq-cre)1Evdr,
Tg(Alb1-cre)1Dlr,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Amh-cre)8815Reb,
Tg(AMH-cre)#Sinos,
Tg(Aqp2-cre)1Dek,
Tg(ARR2/Pbsn-icre)58Atai,
Tg(Atoh1-cre/Esr1*)14Fsh,
Tg(ATP6V1B1-cre)45Rnel,
Tg(Bmx-cre/ERT2)1Rha,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)T29-1Stl,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(Chst4-cre)1Hkwa,
Tg(Ckmm-cre)5Khn,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp11a1-cre)16Mchu,
Tg(Cyp17a1-icre)AJako,
Tg(CYP19A1-cre)1Jri,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(Ddx4-cre)1Ptch,
Tg(Ddx4-cre/ERT2)1Dcas,
Tg(Dhh-cre)1Mejr,
Tg(dlx5a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Elf5-cre/ERT2,-GFP)2Rcha,
Tg(Eno2-cre)2Lfp,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tg(Figla-EGFP,-icre)ZP3Dean,
Tg(FOXJ1-cre)F26Htzm,
Tg(Fshr-cre)1Ldu,
Tg(Gata1-cre)1Sho,
Tg(Gcm1-cre)1Chrn,
Tg(Gdf9-icre)5092Coo,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(GFAP-cre/Esr1*,-lacZ)ASbk,
Tg(GFAP-cre/Esr1*,-lacZ)BSbk,
Tg(GH1-cre)1Sac,
Tg(Gh1-cre)bKnmn,
Tg(Ghrl-cre)E7Jmz,
Tg(Grik4-cre)G32-4Stl,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb7-cre)13Amc,
Tg(Hsd17b1-icre/ERT2)3Casa,
Tg(Hspa2-cre)1Eddy,
Tg(Inha-cre)1Zuk,
Tg(Inha-cre)2Zuk,
Tg(Inha-cre)3Zuk,
Tg(Ins1-cre)25Utr,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Itgax-cre)1-1Reiz,
Tg(Kap-icre)29066/2Sig,
Tg(Kera-cre)KC4.3Wwk,
Tg(Kit-cre)143Hmb,
Tg(KLK3-cre)13Saa,
Tg(Krt13-cre)139Gaff,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre/ERT)20Efu,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Krt18-EGFP,Krt8-cre/ERT)HCmch,
Tg(KRT5-cre)5132Jlj,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(Lck-cre)548Jxm,
Tg(Lck-icre)3779Nik,
Tg(Lcn5-cre/ERT2)#Sxie,
Tg(Lhb-cre)1Sac,
Tg(LTF-EGFP/cre/PGR)15Klin,
Tg(Mbp-cre)6Gvn,
Tg(Mbp-cre)9Gvn,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(MMTV-cre)FMam,
Tg(Msx2-cre)5Rem,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh6-cre)2182Mds,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Neurog3-cre)24Syos,
Tg(Neurog3-cre)C1Able,
Tg(Neurog3-cre/Esr1*)1Dam,
Tg(NPHS2-cre)295Lbh,
Tg(Nr5a1-cre)1Kmor,
Tg(Nr5a1-cre)2Klp,
Tg(Nr5a1-cre)2Lowl,
Tg(Nr5a1-cre)7Lowl,
Tg(Osr1-cre)4Mrt,
Tg(Pax2-cre)10Shwl,
Tg(Pbsn-cre)20Fwan,
Tg(Pbsn-cre)4Prb,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pf4-icre)Q3Rsko,
Tg(Pgk2-cre)1Yna,
Tg(Plp1-cre/ERT)3Pop,
Tg(Pomc1-cre)16Lowl,
Tg(Prdm1-cre)1Masu,
Tg(Pres-cre)1Jnz,
Tg(Prm1-cre)1Osb,
Tg(Prm-cre)58Og,
Tg(Prnp-cre/ERT)28.8Ics,
Tg(Prrx1-cre)1Cjt,
Tg(Ptprc-cre)#Mez,
Tg(Rarb-cre)1Bhr,
Tg(RARE/Hspa1b-cre/ERT2)#Asc,
Tg(REN-cre)1Haca,
Tg(Retnla-cre)#Voeh,
Tg(Rxfp2-cre)1Aia,
Tg(Rxfp2-cre)5Aia,
Tg(S100a4-cre)1Egn,
Tg(Scnn1a-cre)3Aibs,
Tg(Scx-cre)HShuk,
Tg(Sim1-cre)1Lowl,
Tg(Slc26a5-cre)#Jnz,
Tg(Slco1c1-icre/ERT2)1Mash,
Tg(Sox3-cre/ERT2)#Syos,
Tg(Sprr2f-cre)1Dcas,
Tg(Sprr2f-cre)2Dcas,
Tg(Sry-cre)#Masi,
Tg(Stra8-icre)1Reb,
Tg(Sycp1-cre)4Min,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tas2r105-EGFP/cre)#Feli,
Tg(Tas2r143-cre/ERT2)#Soff,
Tg(Tbx18-icre)3Fech,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)5326Sato,
Tg(Tek-icre/ERT2)1Soff,
Tg(Tex101-icre)2Lzj,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tmem100-EGFP/cre/ERT2)30Amc,
Tg(TNS4-cre)1Shlo,
Tg(Tshb-cre)4Sac,
Tg(TSPY1-cre)33aYfcl,
Tg(Ucp1-cre)1Evdr,
Tg(Vav1-cre)1Awr,
Tg(Vav1-cre)8Cgp,
Tg(Vil1-cre)20Syr,
Tg(Vil1-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt7a-EGFP/cre)#Bhr,
Tg(Zbtb16-mCherry,-cre/ERT2)#Rhob,
Tg(Zp3-cre)93Knw,
Thtm1(cre)Te,
Tmprss2tm1.1(cre/ERT2)Ychen,
Trp63tm1.1(cre/ERT2)Jxu,
Trpv4em1(cre/ERT2)Amc,
Ttm1(cre/ERT2)Hssk,
Twist2tm1.1(cre)Dor,
Viptm1(cre)Zjh,
Wt1tm1(EGFP/cre)Wtp
(less)
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J:147304
Fig. 2
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Recombinase Activity
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References
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