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Allele Information
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Allele:
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Tg(CAG-cre/Esr1*)5Amc
transgene insertion 5, Andrew P McMahon
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Driver: CAG
Type: Transgenic
(Inducible, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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CAG-CreEr, CAGG-Cre, CaggCreER, CAGGCre-ER, CAGGCre-ERTM, CAGGCre-ERtm line 5.8, CAGGS-CreER, CAGGS-CreErT, CMV-creERT, Cre-ER, Cre-ERTM, CreESRT, ER-cre, Tg:Cag-Cre/Esr1, Tg(CAG-cre/Esr1)5Amc, TgCAGGCreER, TgCreER, Tg(cre/Esr1)5Amc, uCreERT
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Molecular description:
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This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes.
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Find mice (IMSR):
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Mouse Strains:
10
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(CAG-cre/Esr1*)5Amc activity also observed in:
alimentary system,
branchial arches,
cardiovascular system,
cavities & their linings,
embryo-other,
endocrine system,
head,
hemolymphoid system,
integumental system,
limbs,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
(less)
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Tissue Information
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Adipose Tissue
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Other recombinase alleles with activity in Adipose Tissue tissues:
Alpltm1(cre)Nagy,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cd81em1(cre/ERT2)Kajim,
Cdkn2atm1.1(cre)Dvb,
Commd10Tg(Vav1-icre)A2Kio,
Crhtm1(cre)Zjh,
Dpttm1.1(cre/ERT2)Snjt,
En1tm2(cre)Wrst,
Foxd1tm1(GFP/cre)Amc,
Gad2tm2(cre)Zjh,
Giprem1(icre)Reim,
Glp1rtm1.1(cre)Cors,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
H2az2Tg(Wnt1-cre)11Rth,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Ifi208Tg(Cspg4-cre)1Akik,
Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu,
Islrtm1.1(HBEGF,cre)Mat,
Leprem2(cre/ERT2)Smoc,
Leprtm2(cre)Rck,
Lyve1tm1.1(EGFP/cre)Cys,
Myf5tm3(cre)Sor,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Opn3em1(cre)Lan,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm2.2(flpo)Leol,
Pdgfrbtm1.2(flpo)Leol,
Slc17a6tm2(cre)Lowl,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tg(ACTA1-cre)79Jme,
Tg(Adipoq-cre)1Evdr,
Tg(Adipoq-cre/ERT2)#Wfrm,
Tg(Adipoq-cre)#Pesch,
Tg(CD2-icre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(CMV-cre)1Cgn,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Blw,
Tg(Fabp4-cre)1Rev,
Tg(Fabp4-cre/ERT2)1Ipc,
Tg(GFAP-cre)25Mes,
Tg(Grik4-cre)G32-4Stl,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itgax-cre)1-1Reiz,
Tg(KRT14-cre)1Amc,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-icre/ERT2)1Soff,
Tg(Nes-cre)1Kln,
Tg(Pf4-icre)Q3Rsko,
Tg(Prdm1-cre)1Masu,
Tg(Prrx1-cre)1Cjt,
Tg(Retn-cre)1Laz,
Tg(Retnla-cre)#Voeh,
Tg(S100a4-cre)1Egn,
Tg(Sim1-cre)1Lowl,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(TCF/Lef1-cre/ERT2)#Ypc,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Thy1-cre)1Vln,
Tg(Ucp1-cre)1Evdr,
Tg(Ucp1-cre)#Brsp,
Tg(Wap-cre)11738Mam,
Tg(Wfs1-cre/ERT2)3Aibs,
Twist2tm1.1(cre)Dor,
Ucp1em1(cre)Chez,
Wt1tm1(EGFP/cre)Wtp
(less)
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