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Allele Information
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Allele:
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H2az2Tg(Wnt1-cre)11Rth
H2A.Z histone variant 2;
transgene insertion 11, David H Rowitch
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Driver: Wnt1
Type: Transgenic
(Recombinase)
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Synonym:
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Tg(Wnt1-cre)11Rth, Wnt1-Cre, Wnt1Cre, Wnt1cre, Wnt1::Cre
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Molecular description:
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The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. Line 11 inserted into the gene at 6425500-6456783 (Build GRCm38/mm10) resulting in a 31,283 bp deletion. Founder line x has a copy number of greater than 5.
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Find mice (IMSR):
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Mouse Strains:
2
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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H2az2Tg(Wnt1-cre)11Rth activity also observed in:
adipose tissue,
alimentary system,
branchial arches,
cardiovascular system,
cavities & their linings,
embryo-other,
head,
hemolymphoid system,
integumental system,
limbs,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
(less)
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Tissue Information
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Endocrine System
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Other recombinase alleles with activity in Endocrine System tissues:
7630403G23RikTg(Th-cre)1Tmd,
Agrptm1(cre)Lowl,
Alpltm1(cre)Nagy,
Ccktm1.1(cre)Zjh,
Cfap126tm1.1(icre)Heli,
Commd10Tg(Vav1-icre)A2Kio,
Cpa1tm1(cre/ERT2)Dam,
Crhtm1.1(flpo)Bsab,
Crhtm1(cre)Zjh,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
Cyp11a1tm1(GFP/cre)Pzg,
E2f1Tg(Wnt1-cre)2Sor,
Fgf16tm1.1(cre)Sms,
Foxd1tm1(GFP/cre)Amc,
Foxl2tm1(GFP/cre/ERT2)Pzg,
Gad2tm2(cre)Zjh,
Gcgem1(cre)Utr,
Gcgtm1.1(cre/ERT2)Yasu,
Ghem1(cre)Jmz,
Ghsrtm1.1(cre)Jmz,
Glp1rtm1.1(cre)Cors,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gper1em1(cre)Smoc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Hand2em1(dre)Pjen,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm1(TG-cre)1Sasr,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Ifi208Tg(Cspg4-cre)1Akik,
Ihhem1(Tomm20/mKate2,dre)Xya,
Ins1tm1.1(cre)Thor,
Ins1tm2.1(cre/ERT2)Thor,
Krt17tm1(cre)Murr,
Krt19tm1(cre/ERT)Ggu,
Leprtm2(cre)Rck,
Lyve1tm1.1(EGFP/cre)Cys,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx2-1tm1.1(cre/ERT2)Zjh,
Nkx2-2tm4.1(cre/EGFP)Suss,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Npvftm1.1(icre)Gand,
Nxph4em1(cre)Zak,
Omptm4(cre)Mom,
Oprk1tm1.1(cre)Sros,
Osr2tm2(cre)Jian,
Oxttm1.1(icre)Ksak,
Pax3tm1(cre)Joe,
Pax7tm2.1(cre/ERT2)Fan,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdx1tm1.1(dre)Gkg,
Pdyntm1.1(cre)Mjkr,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prlrtm1.1(cre)Uboe,
Ptf1atm1.1(cre)Cvw,
Ptf1atm1(flpo)Hcrd,
Raxtm1.1(cre/ERT2)Sbls,
Rxfp1em1(cre)Ngai,
Setd4em1(cre)Wjy,
Setd4tm2.1(cre/ERT2)Wjy,
Sfta3tm1.1(cre/ERT2)Eem,
Shhtm1(EGFP/cre)Cjt,
Shhtm2(cre/ERT2)Cjt,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Sox2tm1.1(cre/ERT2)Jpmb,
Spink1tm3(cre)Kymm,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx3em1(cre)Mhts,
Tg(ACTA1-cre)79Jme,
Tg(ACTB-cre)1Tes,
Tg(ACTFLPe)9205Dym,
Tg(Actl6b-cre)4092Jiwu,
Tg(Adipoq-cre)1Evdr,
Tg(Akr1b7-cre)1Anm,
Tg(Alb1-cre)1Dlr,
Tg(Amh-cre)8815Reb,
Tg(Amy2-cre)1Herr,
Tg(CA2-cre)1Subw,
Tg(CA2-cre/Esr1*)1Subw,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)1Nobs,
Tg(Camk2a-cre/ERT2)1Aibs,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)7Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(CMV-cre)1Cgn,
Tg(Crx-cre)1Tfur,
Tg(Cryaa-cre)10Mlr,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp11a1-cre)16Mchu,
Tg(Cyp17a1-icre)AJako,
Tg(Cyp1a1-cre)1Dwi,
Tg(Cyp39a1-cre)1Aibs,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Dbh-cre/ERT2)198.1Hroh,
Tg(Ddx4-cre)1Dcas,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Rev,
Tg(Fev-cre)FF9Pasq,
Tg(Gcg-cre)1Herr,
Tg(Gcg-cre)1Slib,
Tg(Gcg-icre)23Cshi,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(GH1-cre)1Sac,
Tg(Gh1-cre)bKnmn,
Tg(Ghrhr-cre)3242Lsk,
Tg(Ghrl-cre)E7Jmz,
Tg(Ghrl-icre)#Weiz,
Tg(Glp1r-icre)#Fmgb,
Tg(Grik4-cre)G32-4Stl,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Inha-cre)1Zuk,
Tg(Inha-cre)2Zuk,
Tg(Inha-cre)3Zuk,
Tg(Ins1-cre)25Utr,
Tg(Ins1-cre,-DsRed*T3)#Caoy,
Tg(Ins1-cre/ERT)1Lphi,
Tg(Ins1-cre/ERT2)#Pesch,
Tg(Ins2-cre)23Herr,
Tg(Ins2-cre)25Mgn,
Tg(Ins2-cre/ERT)1Dam,
Tg(Ins2-tTA,tetO-cre)1Ctlh,
Tg(INS-icre)18Msdr,
Tg(Itgax-cre)1-1Reiz,
Tg(Lck-icre)3779Nik,
Tg(Lhb-cre)1Sac,
Tg(LHX3-cre)#Sjr,
Tg(Mbp-cre)6Gvn,
Tg(Mbp-cre)9Gvn,
Tg(Mchr1-cre/ERT2)3Nbe,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Nes-cre)1Kln,
Tg(Neurod1-cre)1Able,
Tg(Neurog3-cre)1Dam,
Tg(NEUROG3-cre)1Herr,
Tg(Neurog3-cre)C1Able,
Tg(Neurog3-cre/ERT2)1Able,
Tg(Neurog3-cre/Esr1*)1Dam,
Tg(Nkx2-1-cre)2Sand,
Tg(NPHS2-cre)295Lbh,
Tg(Nr5a1-cre)1Kmor,
Tg(Nr5a1-cre)2Klp,
Tg(Nr5a1-cre)2Lowl,
Tg(Nr5a1-cre)7Lowl,
Tg(Nr5a1-cre/ERT2)4Kmor,
Tg(Pax4-cre)1Dam,
Tg(Pax6-cre)1Rilm,
Tg(Pax6-cre,GFP)1Pgr,
Tg(Pcp2-cre)2Mpin,
Tg(Pdx1-cre)1Herr,
Tg(Pdx1-cre)6Cvw,
Tg(Pdx1-cre)89.1Dam,
Tg(Pdx1-cre/Esr1*)1Mga,
Tg(Pdx1-cre/Esr1*)35.10Dam,
Tg(Pdx1-cre/Esr1*)35.6Dam,
Tg(Pdx1-cre/Esr1*)#Dam,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx1-cre)7Rsd,
Tg(Pomc1-cre)16Lowl,
Tg(Pomc-cre)5Brn,
Tg(Pomc*-cre/ERT2)#Rlb,
Tg(Pomc*-cre)#Jdr,
Tg(Pomc-dre)#Jcbr,
Tg(Prdm1-cre)1Masu,
Tg(Prl-cre)#Salr,
Tg(Prm-cre)58Og,
Tg(Prop1-cre)1Rsd,
Tg(Prop1-icre)517Sac,
Tg(Prrx1-cre)1Cjt,
Tg(PTH-cre)4167Slib,
Tg(Rarb-cre)1Bhr,
Tg(Relb-cre)53Rie,
Tg(REN-cre)1Haca,
Tg(Ren-cre)#Kwg,
Tg(Scnn1a-cre)3Aibs,
Tg(Sim1-cre)1Lowl,
Tg(Stra8-icre)1Reb,
Tg(Sycp1-cre)4Min,
Tg(Tagln-cre)1Her,
Tg(Tek-cre)1Ywa,
Tg(tetO-cre)1Jaw,
Tg(Tg-cre)1Soff,
Tg(Tg-cre/ERT2)1Kero,
Tg(Th-cre)12Mrub,
Tg(Thy1-cre)1Vln,
Tg(TPO-cre)1Shk,
Tg(Tshb-cre)4Sac,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Ucp1-cre)1Evdr,
Tg(Vav1-cre)8Cgp,
Tg(Vil1-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Thtm1(cre)Te,
Tmprss2tm1.1(cre/ERT2)Ychen,
Twist2tm1.1(cre)Dor,
Viptm1(cre)Zjh,
Wt1tm1(EGFP/cre)Wtp
(less)
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Recombinase Activity
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References
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Analysis Tools