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H2az2Tg(Wnt1-cre)11Rth - Extraembryonic Component
Recombinase Activity Detail
Allele Information
Allele:
H2az2Tg(Wnt1-cre)11Rth
H2A.Z histone variant 2; transgene insertion 11, David H Rowitch 		Driver: Wnt1
Type: Transgenic (Recombinase)
Synonym: Tg(Wnt1-cre)11Rth, Wnt1-Cre, Wnt1Cre, Wnt1cre, Wnt1::Cre
Molecular description: The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. Line 11 inserted into the gene at 6425500-6456783 (Build GRCm38/mm10) resulting in a 31,283 bp deletion. Founder line x has a copy number of greater than 5.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: H2az2Tg(Wnt1-cre)11Rth activity also observed in:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 824 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory