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Tg(SERPINA1-cre/ERT)1Ipc - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(SERPINA1-cre/ERT)1Ipc
transgene insertion 1, I Pierre Chambon 		Driver: SERPINA1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: alphaAT-cre-ERT, Tg(SERPINA1-cre/ESR1)1Ipc
Molecular description: This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Liver & Biliary System Other recombinase alleles with activity in Liver & Biliary System tissues:
Images
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J:69327 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory