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Tg(Tagln-cre/ERT2)1Feil - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tagln-cre/ERT2)1Feil
transgene insertion 1, Robert Feil 		Driver: Tagln
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: SM-CreERT2(tg), Tg(Tagln-cre/ESR1)1Feil
Molecular description: An allele encoding a tissue-specific and ligand-dependent recombinase was generated by adjoining cre recombinase/modified estrogen receptor (ESR1) fusion sequence to 5.5 kb of the transgelin promoter and regulatory region. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). The Tagln promoter directed expression in smooth muscle cells. Transgenic expression was detected in smooth muscle tissue but was characterized as being low and mosaic. Recombination was tamoxifen-dependent.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tagln-cre/ERT2)1Feil activity also observed in:
muscle
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:69325 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory