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Taglntm1(cre/ERT2)Feil - Muscle
Recombinase Activity Detail
Allele Information
Allele:
Taglntm1(cre/ERT2)Feil
transgelin; targeted mutation 1, Robert Feil 		Driver: Tagln
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: SM22alphaCew-ERT2, SM-CreERT2(ki), SM-Cre ERT2(ki), SM-CreERT2(ki), Taglntm1(cre/ESR1)Feil
Molecular description: An allele encoding a tissue specific and ligand dependent recombinase was generated by inserting cre recombinase/modified estrogen receptor (ESR1) fusion sequence into the endogenous allele. The ESR1 sequence contained engineered missense mutations at positions 400, 543, 540 which substituted the ability to bind the endogenous ligand with the ability to bind tamoxifen (J:79835). Histochemical analysis of mutant mice treated with tamoxifen showed expression of cre in smooth muscle tissue.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Taglntm1(cre/ERT2)Feil activity also observed in:
alimentary system, cardiovascular system
Tissue Information
Muscle Other recombinase alleles with activity in Muscle tissues:
Images
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J:69325 Fig. 3 J:69325 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 36 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory