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Allele Information
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Allele:
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Gt(ROSA)26Sortm1(cre/ERT)Brn
gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Anton Berns
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Driver: Gt(ROSA)26Sor
Type: Targeted
(Inducible, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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ACM-cre, Cre-ERTm, Gt(ROSA)26Sortm1(cre/Esr1)Brn, R26cre-ERT, R26-CreERT, R26Cre-ERT, Tx-Cre
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Molecular description:
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The endogenous locus was modified by insertion of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT fusion gene, which encodes Cre recombinase joined to the G321R mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Efficient Cre-mediated recombination in transgenic mice carrying floxed reporter genes was reported to reflect constitutive expression of the Gt(ROSA)26Sor from preimplantation stages onward.
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Find mice (IMSR):
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Mouse Strains:
1
strain available
Cell Lines:
0 lines available
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Additional Tissues:
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Gt(ROSA)26Sortm1(cre/ERT)Brn activity also observed in:
alimentary system,
integumental system,
liver & biliary system,
renal & urinary system,
respiratory system
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Tissue Information
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Cavities & Their Linings
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Other recombinase alleles with activity in Cavities & Their Linings tissues:
Alpltm1(cre)Nagy,
Atoh8tm1(EGFP/cre)Gasa,
Bhlhe41em1(cre)Cya,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdh5em1(cre/ERT2)Smoc,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
En1tm2(cre)Wrst,
Flt4tm2.1(cre/ERT2)Sgo,
Foxd1tm1(GFP/cre)Amc,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Igs2tm2(Smarcd3-cre/ERT2)Bbr,
Mecomtm4.1(cre/ERT2)Aspe,
Myf5tm3(cre)Sor,
Nfatc1em4(cre/ERT2)Bzsh,
Nkx2-5tm2(cre)Rph,
Npr3em1(cre/ERT2)Bzsh,
Osr2tm2(cre)Jian,
Pax3tm1(cre)Joe,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Scxtm1.1(cre)Shuk,
Sfrp5tm1.1(cre)Kkb,
Slc17a6tm2(cre)Lowl,
Taglntm2(cre)Yec,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-cre/Esr1*)2Kesr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Ctgf-cre)2Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Epx-EYFP/cre)#Voeh,
Tg(Fabp4-cre)1Rev,
Tg(Flt1-cre/ERT2)1Tmak,
Tg(Gata4*G2-cre)#Roja,
Tg(GATA5-cre)1Krc,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hspa2-cre)1Eddy,
Tg(KRT14-cre)1Amc,
Tg(Mef2c-cre)1Blk,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Prrx1-cre)1Cjt,
Tg(Retnla-cre)#Voeh,
Tg(Sim1-cre)1Lowl,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Tagln-cre)1Her,
Tg(Tbx18-icre)3Fech,
Tg(Tek-cre)1Ywa,
Tg(Thy1-cre)1Vln,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(WT1-cre)AG11Dbdr,
Tg(Wt1-cre)#Jbeb,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre/ERT2)Eno,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp,
Wt1tm2(cre/ERT2)Wtp
(less)
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Images
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J:143936
Fig. 1
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Recombinase Activity
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References
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Analysis Tools