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Tg(Camk2a-cre/ERT2)1Casa - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Camk2a-cre/ERT2)1Casa
transgene insertion 1, Emilio Casanova 		Driver: Camk2a
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: ERiCreER, Tg(Camk2a-cre/Esr1)1Casa
Molecular description: The transgene consists of a BAC vector carrying a tamoxifen-inducible cre recombinase gene under the control of Camk2a regulatory elements, an eGFP cassette, and a bovine growth hormone polyadenylation signal. The cre recombinase gene is flanked by 2 ERT2 ligand binding domains. The Camk2a promoter targets transgene expression to the brain. High expression was observed in the hippocampus and cortex, intermediate expression was observed in the striatum, thalamus, and hypothalamus, and no detectable expression was observed in the cerebellum. This transgenic line carries 8 copies of the integrated construct.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Camk2a-cre/ERT2)1Casa activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:80195 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory