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Tg(Tagln-cre)1Her - Mesenchyme
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tagln-cre)1Her
transgene insertion 1, Joachim Herz 		Driver: Tagln
Type: Transgenic (Recombinase)
Synonym: SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cretg, Tag1-Cre, Tgln-Cre
Molecular description: The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tagln-cre)1Her activity also observed in:
Tissue Information
Mesenchyme Other recombinase alleles with activity in Mesenchyme tissues:
Images
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J:193672 Full Image
Fig. Tagln Embryo 1 E10.5 J:193672 Full Image
Fig. Tagln Embryo 1 E15.5 J:193672 Full Image
Fig. Tagln Embryo 2 E10.5 J:193672 Full Image
Fig. Tagln Embryo 2 E15.5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 298 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory