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Tg(Camk2a-cre/PGR*)1Gsc - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Camk2a-cre/PGR*)1Gsc
transgene insertion 1, Gunther Schutz 		Driver: Camk2a
Type: Transgenic (Inducible, Recombinase)
Inducer: mifepristone
Synonym: CPR1, Tg(Camk2a-cre/PGR)1Gsc
Molecular description: This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand binding domain of the human progesterone receptor under the control of a mouse calcium-calmodulin-dependent kinase IIa promoter. The ligand binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Camk2a-cre/PGR*)1Gsc activity also observed in:
nervous system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory