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Tg(Plp1-cre/ERT)3Pop - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Plp1-cre/ERT)3Pop
transgene insertion 3, Brian Popko 		Driver: Plp1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: PLP/CreER, Plp-CreERt, Plp-Cre-ERT2, Tg(Plp1-cre/ESR1)3.16Pop, Tg(Plp1-cre/ESR1)3Pop, Tg(Plp-cre/ESR1)3.16Pop
Molecular description: The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain cloned next to a Plp promoter. The 2.5 kb Plp regulatory region includes 5' flanking DNA, exon 1, and intron 1. Transgene expression was confirmed by RT-PCR and Western blot analysis. The mouse Plp promoter was used to drive transgene expression in myelinating cells.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Plp1-cre/ERT)3Pop activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:184579 Full Image
Fig. Plp1 Brain Cerebellum P56 J:184579 Full Image
Fig. Plp1 Brain Cortex Cerebellum P56 J:184579 Full Image
Fig. Plp1 Brain P56 J:184579 Full image
Fig. Plp1 Periph Nerve (Lung) P56 J:81627 Fig. 2 J:81627 Fig. 3 J:81627 Fig. 4 J:81627 Fig. 6
J:81627 Fig. 7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 165 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory