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Allele Information
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Allele:
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Tg(Myh11-cre,-EGFP)2Mik
transgene insertion 2, Michael I Kotlikoff
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Driver: Myh11
Type: Transgenic
(Recombinase, Reporter)
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Synonym:
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MH, smMHC-Cre, smMHC/Cre/eGFP, smMHCCre/eGFP, smMHC-Cre-GFPtg, smMHC-Cre-IRES-eGFP, Tg(Myh11-cre/EGFP)1Mik
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Molecular description:
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The transgene consists of a mouse Myh11 promoter, a cre recombinase gene, an internal ribosome entry site (IRES) and an enhanced GFP gene. 16 kb of mouse Myh11 promoter sequences was used to drive the bicistronic transgene expression in smooth muscle cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline.
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Find mice (IMSR):
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Mouse Strains:
1
strain available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Myh11-cre,-EGFP)2Mik activity also observed in:
adipose tissue,
alimentary system,
cardiovascular system,
head,
hemolymphoid system,
integumental system,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs
(less)
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Tissue Information
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Mesenchyme
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Other recombinase alleles with activity in Mesenchyme tissues:
7630403G23RikTg(Th-cre)1Tmd,
Acanem2(dre)Smoc,
Acantm1(cre/ERT2)Crm,
Alpltm1(cre)Nagy,
Alx3em1(cre/ERT2)Lanyu,
Amhr2tm3(cre)Bhr,
Atoh8tm1(EGFP/cre)Gasa,
Bmp7tm6(cre)Rob,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cfap126tm1.1(icre)Heli,
Cldn6tm1(cre/ERT2)Dam,
Col10a1tm2.1(cre)Ksec,
Crhtm1(cre)Zjh,
Ddx4em1(icre)Jobo,
Dmbx1tm3(cre)Aoh,
E2f1Tg(Wnt1-cre)2Sor,
Edil3Tg(Sox2-cre)1Amc,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
Eomestm4.1(icre)Rob,
Fgf18tm2.2(cre/ERT2)Dor,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxa2tm3.1(icre)Heli,
Foxd1tm1(GFP/cre)Amc,
Foxg1tm1(cre)Skm,
Gad2tm2(cre)Zjh,
Gli1tm3(cre/ERT2)Alj,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sortm1(FLP1)Dym,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hand2em1(dre)Pjen,
HhatTg(TFAP2A-cre)1Will,
Hlfem1(cre/ERT2)Smoc,
Hlfem2(cre/ERT2)Suda,
Hnf4atm1(cre)Sdv,
Hoxa3tm1(cre)Moon,
Hoxb1tm1(cre)Og,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Krt19tm1(cre)Mmt,
Lgr6tm2.1(cre/ERT2)Cle,
Lhx1tm1.1(icre)Rob,
Lmx1btm2(cre/ERT2)Rjo,
Ltftm1(icre)Tdku,
Mecomem1(cre/ERT2)Suda,
Mecomtm4.1(cre/ERT2)Aspe,
Megf6em3(cre)Zzhg,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Nkx1-2tm2296.1(cre/ERT2)Arte,
Nkx2-5tm2(cre)Rph,
Nkx3-2tm1(cre)Wez,
Nkx3-2tm3.1(cre)Tlu,
Nkx3-2tm4.1(cre)Tlu,
Notch1tm3(cre)Rko,
Npr3em1(cre/ERT2)Bzsh,
Nrg1em2(cre/ERT2)Bzsh,
Osr1tm1(EGFP/cre/ERT2)Amc,
Osr2tm2(cre)Jian,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pax9tm1.1(cre)Sbam,
Pdgfctm2.1(cre/ERT2)Hdin,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm1.1(flpo)Leol,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Sall4tm1.1(EGFP/cre/ERT2)Ykawa,
Scxtm1.1(cre)Shuk,
Shhtm1(EGFP/cre)Cjt,
Shroom3Gt(ROSA53)Sor,
Six1tm1(cre)Xli,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Smoc2tm1(cre/ERT2)Cle,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx1tm1.1(cre/ERT2)Zzhg,
Tbx5tm1.1(cre/ERT2)Bbr,
Tg(Acan-cre/ERT2,-luc)1Gbg,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(ACTC1-cre)1Miwa,
Tg(Adipoq-cre)1Evdr,
Tg(Alx4-cre/ERT2)1Bky,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)#Ykub,
Tg(Cdx1-cre)23Kem,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Cga-cre)3Sac,
Tg(Cga-icre)961Sac,
Tg(Cited1-cre/ERT2,-EGFP)1Mdca,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1And,
Tg(Col10a1-cre)1465Vdm,
Tg(Col10a1-cre)1466Vdm,
Tg(Col10a1-cre)1Xya,
Tg(Col10a1-cre)#Ksec,
Tg(Col11a2-cre)4Nhzi,
Tg(Col1a1-cre)#Xya,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Col2a1-cre/ERT)1Flng,
Tg(Col2a1-cre/ERT2)1Dic,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Col2a1-rtTA,tetO-cre)22Pjro,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp39a1-cre)1Aibs,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre/ERT2)#Mpac,
Tg(Dll1-cre)1Gos,
Tg(Dll1-cre)33Dchp,
Tg(Dll4-cre)#Xia,
Tg(dlx5a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Etv2-cre)15508Djg,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Fev-cre)FF9Pasq,
Tg(Foxa3-cre)1Khk,
Tg(Foxl1-cre)1Khk,
Tg(Frzb-cre)1Tylz,
Tg(GATA5-cre)1Krc,
Tg(Gdf5-cre,-ALPP)1Kng,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hand2-cre)7-1Clou,
Tg(Hes7-cre)1Kag,
Tg(Hoxa2-cre)1Dym,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre/ERT)1Smac,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Mef2c-cre)1Blk,
Tg(mI56i-cre)6-2Clou,
Tg(Mnx1-cre/ERT2)8Rbro,
Tg(Mpz-cre)1Brn,
Tg(Mpz-cre)94Imeg,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Myh6-cre)2182Mds,
Tg(Myl1-cre)13Nros,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre)1Wmz,
Tg(Nkx2-1-cre)2Sand,
Tg(NKX2-5-cre)#Kyuhl,
Tg(NKX2-5*-cre)#Kyuhl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Nrp2-cre/ERT2,-Kikume)1Qsch,
Tg(Osr1-cre)4Mrt,
Tg(Pax2-cre)10Shwl,
Tg(Pax3-cre)1Joe,
Tg(Pax3-cre)2Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(POU3F4-cre)M51Cren,
Tg(Pou4f3-cre)1Devet,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Mpac,
Tg(Prg4-cre)#Mkaz,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-cre/ERT2)1Mlgn,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Rr437-cre)#Hmd,
Tg(Rr456-cre/Esr1*)7Hmd,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(Rxfp2-cre)1Aia,
Tg(Rxfp2-cre)5Aia,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scx-cre)HShuk,
Tg(Scx-cre)LShuk,
Tg(Sim1-cre)1Lowl,
Tg(Six1-cre)2Kwk,
Tg(Smad7-cre)1Sjc,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Sox10-cre)507Mcln,
Tg(Sox10-ERT2/cre/ERT2)17Sor,
Tg(Sox10-icre/ERT2)388Wdr,
Tg(Sox2-flpo)#Mhem,
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc,
Tg(Stab2-icre)1.2Cger,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx1-cre)1Joe,
Tg(Tbx4-cre)6Kras,
Tg(Tbx4-cre/ERT2)#Kras,
Tg(Tbx6-cre)#Rsam,
Tg(T-cre)1Gos,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Ymor,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(Wnt1-cre/ERT)1Alj,
Tg(Wt1-cre)1Jbeb,
Tg(Wt1-cre)#Jbeb,
Ttm1(cre/ERT2)Hssk,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre)Dor,
Vimem1(cre/ERT2)Bzsh,
Wnt6tm1(cre)Mrc,
Wt1em1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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Recombinase Activity
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References
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