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Edil3Tg(Sox2-cre)1Amc - Embryo-other
Recombinase Activity Detail
Allele Information
Allele:
Edil3Tg(Sox2-cre)1Amc
EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon 		Driver: Sox2
Type: Transgenic (Null/knockout, Recombinase)
Synonym: Sox2-cre, Sox2::Cre, Sox2Cre, Sox2-Cretg, Tg(Sox2-cre)1Amc
Molecular description: This transgene expresses Cre recombinase under the control of a mouse Sox2 promoter contained in 12.5 kb of upstream DNA. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline, cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos regardless of whether or not they inherit the transgene. Line 1 inserted into an intron of the gene at 89311726-89311727 (Build GRCm38/mm10) resulting in a functional knockout of the gene. Founder line 1 has a copy number of 2-5.
Find mice (IMSR): Mouse Strains: 5 strains available       Cell Lines: 0 lines available
Additional Tissues: Edil3Tg(Sox2-cre)1Amc activity also observed in:
extraembryonic component, mesenchyme
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
Images
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J:83040 Fig. 1 J:83040 Fig. 2 J:83040 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 528 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory