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Tg(Plp1-cre/ERT2)1Ueli - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Plp1-cre/ERT2)1Ueli
transgene insertion 1, Ueli Suter 		Driver: Plp1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: PLP-CreERT2, PLP/Cre-ERT2, Tg(Plp1-cre/ESR1)1Ueli
Molecular description: The transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodendrocytes and Schwann cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Plp1-cre/ERT2)1Ueli activity also observed in:
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:277754 Fig. 2 J:277754 Fig. 3 J:277754 Fig. S4 J:277754 Fig. S7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 56 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory