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Tg(Mpz-cre/ERT2)2Ueli - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Mpz-cre/ERT2)2Ueli
transgene insertion 2, Ueli Suter
Driver: Mpz
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: P0-CreERT2, P0Cx-CreERT2, Tg(Mpz-cre/ESR1)2Ueli
Molecular description: 1.1 kb of rat Mpz promoter sequences control the expression of 350 bp from the 5' untranslated region of the human GJB1 gene and a cre-ESR1 cassette in Schwann cells. The GJB1 region includes exon 1, intron 1, and exon 2. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory