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Tg(Itga2b-cre)NE1/21Emam - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Itga2b-cre)NE1/21Emam
transgene insertion NE1/21, Nikla R Emambokus 		Driver: Itga2b
Type: Transgenic (Recombinase)
Synonym: gpIIb-Cre
Molecular description: The transgenic construct was comprised of an integrin alpha 2b genomic fragment, including 2.5 kb of promoter through 2.8 kb of intron 1, adjoined to sequence encoding cre recombinase with a nuclear localization signal. The cassette containng NLS-cre also contained a splice acceptor site, IRES, and a polyadenylation signal. The integrin alpha 2b promoter drives expression of cre recombinase at the site of emergence of hematopoietic progenitors in the yolk sac, aorta-gonad-mesonephros region, and fetal liver. Founder mice contained between 2 and 5 copies of the transgene.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Itga2b-cre)NE1/21Emam activity also observed in:
extraembryonic component, hemolymphoid system, liver & biliary system, mesenchyme, reproductive system, skeletal system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory