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Tg(CAG-cre/Esr1*)1Lbe - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(CAG-cre/Esr1*)1Lbe
transgene insertion 1, Corrinne Lobe 		Driver: CAG
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: actin-creER, beta-actin-CreER, CAGG-CreER, CX-CreERx, pCX-CreERTM, Tg(ACTB-cre/Esr1)1Lbe, Tg(CAG-cre/Esr1)1Lbe
Molecular description: This transgenic construct was generated by ligating sequence encoding a fusion protein of cre recombinase and a mutant mouse estrogen receptor ligand binding domain to a CMV early enhancer and chicken beta-actin promoter. In the absence of ligand binding, the fusion protein remains in the cytoplasm. Binding of 4-hydroxytamoxifen enables the fusion protein to move to nucleus where it may act upon DNA. This transgenic line was generated by electroporating the contstruct into ES cells. Expression of the fusion protein was in a widespread mosaic pattern. Two lines were generated, BD8 with two copies of the transgene and CA6 with one copy.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(CAG-cre/Esr1*)1Lbe activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:81562 Fig. 4 J:81562 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 40 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory