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Tg(Nppa-cre)3Vmc - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nppa-cre)3Vmc
transgene insertion 3, Vincent M Christoffels 		Driver: Nppa
Type: Transgenic (Recombinase)
Synonym: -3/+4mCre, Nppa-Cre3
Molecular description: The transgenic construct consisted of a sequence fragment encoding cre recombinase, a nuclear localization signal, and a consensus Kozak signal inserted at the start codon of the mouse genomic Nppa sequence. The 0.7 kbp Nppa proximal promoter region (-3kbp to +4 kbp relative to the transcription start site) was included. The mouse Nppa proximal promoter drives expression of cre recombinase in atrial cardiomyocytes beginning around E10.5. Complete expression is observed around E14.5. Some expression was observed in the inflow tract. Greater atrial specificity resulted in further analysis of this mouse line.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nppa-cre)3Vmc activity also observed in:
embryo-other, muscle
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:86158 Fig. 1 J:86158 Fig. 2 J:86158 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory