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HhatTg(TFAP2A-cre)1Will - Mesenchyme
Recombinase Activity Detail
Allele Information
Allele:
HhatTg(TFAP2A-cre)1Will
hedgehog acyltransferase; transgene insertion 1, Trevor Williams 		Driver: TFAP2A
Type: Transgenic (Null/knockout, Recombinase)
Synonym: Ap2-Cre, AP-2CRE, CrefaceT, Tg(TFAP2A-cre)1Will
Molecular description: This transgenic construct consisted of 200 bp of human TFAP2A (TCFAP2A) promoter sequence (encoding a specific enhancer element) followed by NLS-cre, an SV40 polyA signal, and a 1.8 kb TFAP2A genomic fragment extending from within exon 5 through a portion of exon 6. The human intron 5 sequence includes the frontonasal prominence- and limb-specific enhancer. Expression of cre recombinase was detected in the embryonic face and limb mesenchyme. New research has determined that the transgene inserted into intron 9 of the Hhat locus. This insertion creates a non-functional allele.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: HhatTg(TFAP2A-cre)1Will activity also observed in:
Tissue Information
Mesenchyme Other recombinase alleles with activity in Mesenchyme tissues:
Images
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J:88829 Fig. 2 J:88829 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory