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Tg(Wap-rtTA-cre)10Whl - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Wap-rtTA-cre)10Whl
transgene insertion 10, Wen-Hwa Lee 		Driver: Wap
Type: Transgenic (Recombinase, Transactivator)
Synonym: TgWAPrtTACre, Wap-cre, WAPCrec, Wap-rtTA-Cre
Molecular description: Sequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory