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Tg(Pax2-cre)1Akg - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Pax2-cre)1Akg
transgene insertion 1, Andrew K Groves 		Driver: Pax2
Type: Transgenic (Recombinase)
Synonym: Pax2-Cre
Molecular description: A 121kb segment of the Pax2 gene which included 101 kb of sequence upstream of exon1, all of exons 1 and 2, part of exon 3, as well as introns 1 and 2, was modified by the insertion of IRES-cre into exon 2. Cre expression was demonstrated in the otic placode starting at the 6-7 somite stage. Cre expression also occurred in the midbrain-hindbrain boundary and the embryonic kidney. Two founders showed germline transmission of cre, and the line that displayed stronger cre mRNA expression was designated by MGI as line 1.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Pax2-cre)1Akg activity also observed in:
branchial arches, embryo-other, head, renal & urinary system, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:89784 Fig. 2 J:89784 Fig. 3 J:89784 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 135 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory