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Tg(HBB-cre)27053Kpe - Embryo-other
Recombinase Activity Detail
Allele Information
Allele:
Tg(HBB-cre)27053Kpe
transgene insertion 27053, Kenneth Peterson 		Driver: HBB
Type: Transgenic (Recombinase)
Synonym: Tg(HBB-cre)27053Tpa
Molecular description: This transgene expresses Cre recombinase under the control of a human beta-globin gene promoter and a beta-globin locus control region (LCR). The inserted copy number was determined to be 2. Expression of Cre was determined by crosses to a reporter strain, and was shown to be present in the erythroid compartment throughout development, including the yolk sac during primitive erythropoiesis, the liver during fetal definitive erythropoiesis and the bone marrow during adult definitive erythropoiesis. Cre activity was also noted in the peripheral circulation during development, in the adult liver and in some megakaryocytes. No expression in the germ line was detected.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(HBB-cre)27053Kpe activity also observed in:
extraembryonic component, hemolymphoid system, liver & biliary system, skeletal system
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
Images
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J:89725 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory