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Allele Information
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Allele:
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A1cfTg(Myh6-cre/Esr1*)1Jmk
APOBEC1 complementation factor;
transgene insertion 1, Jeffery D Molkentin
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Driver: Myh6
Type: Transgenic
(Inducible, Null/knockout, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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alphaMHC-Cre-Mer-Cre, alpha-MHC-MerCreMer, CM-MCM, MCM, mer, mER-CRE-mER, MerCreMer, Myh6-MerCreMer, Myh6:MerCreMer, Tg(Myh6-cre/Esr1)1Jmk
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Molecular description:
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This transgene expresses a cre recombinase/ mutant estrogen receptor ligand binding domain fusion protein under the control of a mouse cardiac-specific alpha-myosin heavy chain promoter. Expression was detected in the juvenile and adult heart, but the protein is inactive until induced with tamoxifen. Integration of the transgene in to Chr. 19 deleted a 19,500 bp fragment including the promoter, exon 1, and part of intron 1 of the A1cf gene. Western analysis of liver from homozygous transgenic mice does not detect A1cf protein.
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Find mice (IMSR):
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Mouse Strains:
5
strains available
Cell Lines:
0 lines available
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Additional Tissues:
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A1cfTg(Myh6-cre/Esr1*)1Jmk activity also observed in:
cardiovascular system
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Tissue Information
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Muscle
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Other recombinase alleles with activity in Muscle tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Acantm1(cre/ERT2)Crm,
Aldh1l1em1(cre/ERT2)Nju,
Alpltm1(cre)Nagy,
Aplntm1.1(cre/ERT2)Bzsh,
Atoh8tm1(EGFP/cre)Gasa,
Cacna1htm2.1(cre)Glwn,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdh5em1(cre/ERT2)Smoc,
Chattm2(cre)Lowl,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Dmp1tm1(cre)Msue,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Etv1tm1.1(cre/ERT2)Zjh,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxd1tm1(GFP/cre)Amc,
Gad2tm2(cre)Zjh,
Gjd3tm1.1(cre/EGFP)Nmun,
Gli1tm3(cre/ERT2)Alj,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(FLP1)Dym,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hand1tm1.1(EGFP/cre)Abfi,
Hcn4tm1(cre/ERT2)Anlu,
HhatTg(TFAP2A-cre)1Will,
Hic1tm2.1(cre/ERT2)Tmun,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Hsd11b2tm1(cre)Anft,
Ifi208Tg(Cspg4-cre)1Akik,
Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu,
Igs2tm2(Smarcd3-cre/ERT2)Bbr,
Isl1tm1(cre/Esr1*)Krc,
Isl1tm1(cre)Sev,
Isl1tm1(cre)Tmj,
Kdrtm1(cre)Sato,
Kittm1.1(cre)Jmol,
Krt17tm1(cre)Murr,
Leprtm2(cre)Rck,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mgptm1.1(cre)Borr,
Mnx1tm4(cre)Tmj,
Myf5tm1.1(cre/Esr1*)Trdo,
Myf5tm1.1(cre)Mrc,
Myf5tm1(cre/Esr1*)Trdo,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Myf6tm1.1(cre/ERT2)Lepr,
Myf6tm1.1(cre/Esr1*)Cklr,
Myf6tm1(cre)Mrc,
Myf6tm2(cre)Mrc,
Myh6em2(cre)Smoc,
Myl1tm1.1(cre/ERT2)Lepr,
Myl2tm1(cre)Krc,
Myocdtm1(cre)Dzw,
Myocdtm1(cre)Jomm,
Myod1tm1.1(cre/ERT2)Lepr,
Myod1tm2.1(icre)Glh,
Myogtm1.1(cre/ERT2)Lepr,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nfatc1em4(cre/ERT2)Bzsh,
Nfatc1tm1.1(cre/ERT2)Bzsh,
Nkx2-5tm1(cre)Rjs,
Nkx2-5tm2(cre)Rph,
Nos1tm1.1(cre/ERT2)Zjh,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Oprk1tm1.1(cre)Sros,
Osr2tm2(cre)Jian,
P2rx2tm1.1(cre)Ttc,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pax7tm1(cre/ERT2)Gaka,
Pax7tm1(cre/Esr1*)Cklr,
Pax7tm1(cre)Mrc,
Pax7tm2.1(cre/ERT2)Fan,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(cre/ERT2)Trdo,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfrbtm1.1(cre/ERT2)Csln,
Pitx2tm4(cre)Jfm,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pms2tm2(cre)Lisk,
Pvalbtm1(cre)Arbr,
Runx3tm1(flpo)Noo,
Scxtm1.1(cre)Shuk,
Sema3atm1.1(cre/ERT2)Bzsh,
Shhtm1(EGFP/cre)Cjt,
Shroom3Gt(ROSA53)Sor,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm1(cre/ERT2)Feil,
Taglntm2(cre)Yec,
Tbx1tm6(cre)Bld,
Tcf7l2tm3.1(cre/ERT2)Mrc,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(ACTA1-cre/ERT2)97.16Mtz,
Tg(ACTA1-cre/Esr1*)2Kesr,
Tg(ACTA1-rtTA,tetO-cre)102Monk,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)1Ikal,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTC1-cre)1Miwa,
Tg(Alb1-cre)1Dlr,
Tg(Bmx-cre/ERT2)1Rha,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-cre/Esr1*)86Lbgn,
Tg(Camk2a-cre/ERT2)1Aibs,
Tg(CD2-icre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cga-cre)3Sac,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1And,
Tg(CMV-cre)1Cgn,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Colq-cre)#Kohno,
Tg(Csf1r-icre)1Jwp,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp1a1-cre)1Dwi,
Tg(Cyp39a1-cre)1Aibs,
Tg(Dct-cre)1Apdn,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tg(Fabp4-cre/ERT2)1Ipc,
Tg(Fgfr3-icre/ERT2)4-2Wdr,
Tg(Gabra6-cre)B1Lfr,
Tg(Gata1-cre)1Sho,
Tg(GATA5-cre)1Krc,
Tg(GATA6-cre)#Jbeb,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(Gjb6-cre/ERT2)53-33Fwp,
Tg(Glp1r-icre)#Fmgb,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand1-EGFP/cre)#Abfi,
Tg(Hoxb8-cre)1403Uze,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itgax-cre)1-1Reiz,
Tg(Kcne1-cre/ERT2)1Imos,
Tg(KRT14-cre)1Amc,
Tg(Mef2c-cre)1Blk,
Tg(Mef2c-cre)2Blk,
Tg(Mef2c-cre)#Blk,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-cre/ERT2)F31Gko,
Tg(Myh11-dre/ERT2)#Cya,
Tg(Myh11-icre/ERT2)1Soff,
Tg(Myh6-cre)1Xya,
Tg(Myh6-cre)2182Mds,
Tg(Myh6-cre/PGR*)1Mds,
Tg(Myh6-cre/PGR*)6297Mds,
Tg(Myh7-cre)1Zli,
Tg(Myl1-cre)13Nros,
Tg(myl7.L-cre)1118Tmhn,
Tg(MYOD1-cre)M23Glh,
Tg(Myog-cre)1Eno,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nkx2-5-cre)9Eno,
Tg(Nppa-cre)3Vmc,
Tg(Opn4-cre)#Yau,
Tg(Osr1-cre)4Mrt,
Tg(Pax3-cre)2Joe,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Pitx3-cre/ERT2)1Yqd,
Tg(Plp1-cre/ERT)3Pop,
Tg(Postn-icre/ERT2)#Wet,
Tg(Prdm1-cre)1Masu,
Tg(Prg4-cre/ERT2)#Ndy,
Tg(Prrx1-cre)1Cjt,
Tg(Rr437-cre)#Hmd,
Tg(rtetR-tetO-cre)1Mhz,
Tg(S100a4-cre)1Egn,
Tg(Scx-cre)HShuk,
Tg(Sim1-cre)1Lowl,
Tg(Slc1a3-cre/ERT2)45-72Fwp,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tagln-cre)1Llw,
Tg(Tagln-cre/ERT2)1Feil,
Tg(Tagln-rtTA-cre)1Llw,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(Tbx18-icre)3Fech,
Tg(Tbx1-cre)1Joe,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)5326Sato,
Tg(Tek-icre/ERT2)1Soff,
Tg(Thy1-cre)1Vln,
Tg(Tnni3-cre/GFP)1Mknn,
Tg(Tnnt2-cre)5Blh,
Tg(Vav1-cre)1Awr,
Tg(Vav1-cre)8Cgp,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(Wt1-cre)1Jbeb,
Tg(WT1-cre)AG11Dbdr,
Thtm1(cre)Te,
Tnni3tm1(EGFP/cre/ERT2)Wtsi,
Twist2tm1.1(cre)Dor,
Twist2tm1(cre/ERT2)Eno,
Viptm1(cre)Zjh,
Wt1tm1(EGFP/cre)Wtp,
Wt1tm2(cre/ERT2)Wtp
(less)
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Images
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Reset Images
J:206504
Full Image
Fig. Myh6 Adult Lung
J:337240
Fig. 4
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Recombinase Activity
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References
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Analysis Tools