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Tg(Chx10-EGFP/cre,-ALPP)2Clc - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Chx10-EGFP/cre,-ALPP)2Clc
transgene insertion 2, Constance L Cepko 		Driver: Vsx2
Type: Transgenic (Recombinase, Reporter)
Synonym: Chx10 BAC, Chx10 BAC line 2, Chx10-cre, Chx10::Cre, Chx10CreGFP, Tg(Chx10-EGFP/cre-ALPP)2Clc, Tg(Chx10-GFP/cre, ALPP)2Clc/J, Tg(Vsx2-EGFP/cre-ALPP)2Clc
Molecular description: This reporter gene expresses an enhanced green fluorescent protein-Cre recombinase fusion protein and alkaline phosphatase under control of Chx10 promoter and enhancer elements.The transgene was generated in a 129/Sv-derived bacterial artificial chromosome (BAC) containing the Chx10 gene and extending approximately 55 kb upstream of the translation start site and about 22 kb downstream of the polyadenylation signal. The 8th codon of Chx10 is joined in-frame to an EGFP-cre fusion gene followed by an internal ribosome entry sequence (IRES) coupled to the human placental alkaline phosphatase gene; 32 codons are deleted from within the N-terminal coding sequence of Chx10. The transgene was found by Southern blot analysis to be present in multiple copies, most or all of them intact. The mice were crossed to 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J mice to remove the FRT-flanked selection cassette.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Chx10-EGFP/cre,-ALPP)2Clc activity also observed in:
sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:237527 Fig. Supplemental 1 J:91498 Fig. 1 J:91498 Fig. 2 J:91498 Fig. 3 J:91498 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 123 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory