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Tg(Neurog3-cre)C1Able - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Neurog3-cre)C1Able
transgene insertion C1, Andrew B Leiter 		Driver: Neurog3
Type: Transgenic (Recombinase)
Synonym: Neurgo3TgBAC-Cre, Neurog3(cre), Neurog3Cre, ngn3-Cre, Tg(Neurog3-cre)#Able
Molecular description: The Cre recombinase coding sequence, flanked by a nuclear localization signal and an SV40 polyadenylation site, was inserted just after the translation start site of the neurogenin 3 gene present in mouse BAC RP23-121F10, which also includes approximately 81 kb of 5' and 102 kb of 3' flanking DNA. Immunohistochemical analysis shows the same expression pattern for cre as for neurogenin 3 in adult and embryonic mice bearing this transgene. Cre recombinase activity is seen in cell types of pancreas, stomach, small intestine and colon that express or are descended from cells that express neurogenin 3 during development.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Neurog3-cre)C1Able activity also observed in:
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:184579 Full Image
Fig. Neurog3 Pancreas P56 J:184579 Full Image
Fig. Neurog3 Pancreas P7 J:92204 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 92 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory